General Pathology US Medical PG Flashcards - Medical Study Cards
Master General Pathology with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
General Pathology Flashcard Deck - 10 Cards
Flashcard 11: What is the underlying biochemical defect in I-cell disease (inclusion cell disease)?
Answer: Defect in N-acetylglucosaminyl-1-phosphotransferase → Failure of Golgi to phosphorylate mannose residues (decreased M6P) → Proteins are secreted extracellularly rather than delivered to lysosomes.
Extra: - Clinical features: Coarse facial features, clouded corneas, restricted joint movement, and claw hand deformities.
- Laboratory: High plasma levels of lysosomal enzymes.
- Genetics: Autosomal Recessive (AR).
- Inclusion bodies: Seen on biopsy (hence the name).
Flashcard 12: Scleroderma is characterized by _____ activation with resultant collagen deposition
Answer: fibroblast
Extra:
* Fibroblasts activated by IL-13 & TGF-β
https://onlinemeded.org/spa/rheumatology/other-connective-tissue/acquire?ref=anki
Flashcard 13: _____ tests or Blood (ELISA) tests for allergen-specific IgE are typically used to diagnose type I hypersensitivity reactions
Answer: Skin prick
Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/immunology/videos/hypersensitivities?index=2]
https://onlinemeded.org/spa/dermatology/hypersensitivity/acquire?ref=anki
Flashcard 14: Hereditary spherocytosis will show _____ mean fluorescence of RBCs in eosin 5-maleimide (EMA) binding test
Answer: decreased
Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/normocytic-anemia?index=10]
https://onlinemeded.org/spa/genetics?ref=anki
Flashcard 15: In addition to RBCs, megaloblastic anemia also leads to megaloblastic change in cells that are _____
Answer: rapidly-dividing
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/macrocytic-anemia?index=2]
https://onlinemeded.org/spa/hematology-oncology/macrocytic-anemia/acquire?ref=anki
Atlas:
Other:
Flashcard 16: Which cellular change is characterized by an increased number of cells?
_____
Answer: Hyperplasia
Extra:
https://onlinemeded.org/spa/inflammation-and-neoplasia/cellular-adaptations/acquire?ref=anki
Flashcard 17: Histoplasma will characteristically present on histology as _____ with _____ bodies
Answer: macrophages
Extra: Histoplasma capsulatum is a systemic dimorphic fungus found in soil with bird or bat droppings (Mississippi and Ohio River valleys).
Histology: Macrophages filled with small intracellular yeasts (2-4 µm) with narrow-based budding. They are much smaller than red blood cells.
Flashcard 18: What type of scar extends beyond the borders of the original wound?
_____
Answer: Keloid scar
Extra:
https://onlinemeded.org/spa/inflammation-and-neoplasia/wound-healing/acquire?ref=anki
Flashcard 19: _____-cytosis refers to cells of varying sizes
Answer: Aniso
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/blood-cells?index=4]
https://onlinemeded.org?ref=anki
Flashcard 20: Oligodendrocytes have a "_____" appearance histologically
Answer: fried egg
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/neurology/videos/cellular-function?index=2]
https://onlinemeded.org/spa/neurology?ref=anki
Keywords: General Pathology flashcards, medical flashcards, NEET PG preparation, USMLE Step 1 flashcards, Anki alternative, spaced repetition medical, OnCourse flashcards
