General Pathology — Flashcards

Flashcard 151: Cell surface markers CD1-CD8 = _____-cell Cell surface markers CD10-CD23 = _____-cell

Answer: T

Extra:  https://onlinemeded.org/spa/hematology-oncology/lymphoma/acquire?ref=anki 

Flashcard 152: Large fluid-containing blister > 1 cm = _____

Answer: bulla

Extra:  https://onlinemeded.org/spa/dermatology/hyperpigmentation/acquire?ref=anki 

Flashcard 153: What is the normal range of Hematologic: Thrombin time?

Answer: From 0 to 2 seconds deviation from control

Flashcard 154: Identify the conditions associated with each of the following: - Mutation in type V collagen with joint hypermobility - Mutation in type I collagen with spontaneous fractures - Lack of hydroxylation of proline and lysine presenting with bleeding gums

Answer: - Ehlers-Danlos syndrome (Classical type) - Osteogenesis imperfecta - Scurvy

Flashcard 155: 10 y/o boy comes to the office for visit. -Has required several blood product transfusions due to anemia. -His parent does not have prior records available with her. -Physical exam: conjunctival pallor & moderate splenomegaly. -Lab: Hemoglobin 9.4 g/dL Platelets     240,000/mm -Enzyme assays: Low pyruvate kinase activity -What is the most likely cause of this patient's splenomegaly?

Answer: Red pulp hyperplasia. (splenomegaly) due to Pyruvate kinase deficiency, lack of ATP, which lead to deform RBC (hemolytic anemia) that lead to overworking spleen to destroy those RBC & remove them, lead to red pulp hyperplasia inside the spleen.

Flashcard 156: The PD1 receptor is normally involved in the maintainance of _____ immunologic tolerance

Answer: peripheral

Flashcard 157: Which MHC class is expressed on all nucleated cells and platelets? _____

Answer: MHC I

Flashcard 158: What is the most common mechanism of chromosomal aneuploidy? _____

Answer: Meiotic nondisjunction

Flashcard 159: When HLA typing and testing for a Mixed lymphocyte reaction, _____ radioactivity signifies lower compatibility

Answer: higher

Flashcard 160: McCune-Albright syndrome is lethal if the mutation occurs before fertilization (affecting all cells), but survivable in patients with _____

Answer: mosaicism