General Pathology — Flashcards

Which cellular change is characterized by decreased cell production during embryogenesis? _____

_____ involves the controlled proliferation of stem cells and differentiated cells

Hint: (hypertrophy or hyperplasia)

Reticulocytes have a bluish cytoplasm on Wright-Giemsa stain due to presence of residual _____

What is the mode of inheritance of porphyria cutanea tarda? _____

Type II Hypersensitivity Disorders - Cytotoxic: **Transfusion Reaction** - Antibody against _____ - IgM isohemagglutinins naturally formed in response to bacterial flora cause opsonization and complement activation, leading to hemolysis **Hemolytic Disease of the Newborn (Erythroblastosis fetalis)** Antibody = Anti-RhD+ IgG - Formed in Rh- mother carrying Rh+ child - First pregnancy sensitizes (doesn't have to be viable pregnancy) - Antibody crosses placenta and injures subsequent fetuses - Prevent with RhoGAM (anti-Rh, binds fetal red cells and prevents mother's immune system from reacting) ABO blood typing and screening for other preformed Abs: Universal donor: type O Universal recipient: type AB (Ex) Type A can donate to type A and type AB. Type A can receive donations from type A and type O. - Anti-B antibodies prevent donation from type B and type AB. HLA Typing - Microcytotoxicity test - Tests for MHC class I (HLA-A, HLA-B) - Test hundreds of different haplotypes to find a potential match. - Cells recognized by antibody will be attacked by complement and thus become leaky and take up dye. HLA Typing - Mixed lymphocyte reaction - Tests for MHC class II (HLA-DR) - Take donor cells and irradiate them (prevent proliferation). Irradiated donor cells are mixed with recipient cells to see if proliferation occurs. - Higher radioactivity (thymidine) signifies lower compatibility.

What component of the breast is affected in fat necrosis? _____

_____ refers to an increased number of circulating lymphocytes

Asbestos bodies contain _____ and thus may be visualized using a(n) _____ stain

The intermediate filament Cytokeratin is found in _____ cells

Which type of calcification occurs in abnormal, necrotic tissues? _____

Hint: dystrophic or metastatic