Molecular Genetics — Flashcards

Flashcard 771: _____ uses a fluorescent DNA/RNA probe to bind to a specific gene of interest on chromosomes

Answer: Fluorescence in situ hybridization (FISH)

Flashcard 772: What class of diseases is Fragile X syndrome a part of?_____

Answer: Trinucleotide repeat expansion diseases

Flashcard 773: Which cell cycle checkpoint is blocked by p53?_____

Answer: G1 to S

Flashcard 774: Once hyperphosphorylated, Rb releases the E2F transcription factor which initates the _____ phase

Answer: S

Flashcard 775: Which pyrimidine is characterized by no amino group at the 12 o'clock position AND no methyl group(s)?_____

Answer: Uracil

Flashcard 776: Drugs that block DNA replication often have a modified _____, preventing addition of the next nucleotide ("chain termination")

Answer: 3' OH

Flashcard 777: Sickle cell anemia is caused by a mutation in the _____ chain of hemoglobin

Answer: Beta (β) chain

Extra: Sickle cell anemia is caused by a missense mutation in the β-globin gene (on chromosome 11), leading to the substitution of glutamic acid with valine at the 6th position of the β-globin chain.

Flashcard 778: One feature of the genetic code is that it is _____: genetic code is conserved throughout evolution

Answer: universal

Flashcard 779: Are RNA and protein typically fragmented before analysis? _____

Answer: No

Flashcard 780: IgA exists as a _____ in circulation

Answer: monomer