Molecular Genetics — Flashcards

What is the mode of inheritance of Hurler syndrome?_____

What is the effect of increased G-C content on the melting temperature of a DNA strand?_____

Which pyrimidine is characterized by the presence of methyl groups, but no amino group at the 12 o'clock position?_____

What is the mode of inheritance of Fabry disease?_____

The _____ is a Y-shaped region along the DNA template where leading and lagging strands are synthesized

What form of chromatin is transcriptionally inactive and sterically inaccessible? _____

Topoisomerase _____ induces breaks in both the positive and negative DNA strands (double stranded breaks)

Sickle cell trait results in _____ 50% HbS in RBCs

A _____ is detected with FISH as an extra site of fluorescence on one chromosome relative to its homologous chromosome

The APC tumor suppresor regulates the Wnt signalling pathway by destroying _____ in the absence of a Wnt receptor-ligand interaction