Molecular Genetics — Flashcards

Flashcard 531: What is the mechanism of oncogene activation for **N-MYC**?

Answer: Gene amplification

Extra: N-MYC (MYCN) amplification is classically associated with **neuroblastoma** and indicates a poor prognosis. Note: N-MYC is located on chromosome 2.

Flashcard 532: The TSH receptor on the thyroid follicular cells may be stimulated by _____ in Graves Disease

Answer: TSI (thyroid-stimulating immunoglobulin)

Flashcard 533: NF2 is a tumor suppressor gene that encodes for the protein _____

Answer: merlin (schwannomin)

Flashcard 534: Microsatellites are repeating sequences of _____ DNA (coding or non-coding)

Answer: non-coding

Flashcard 535: Which type of DNA mutation causes the most severe damage? _____

Answer: frameshift mutations

Flashcard 536: What is the mode of inheritance of neurofibromatosis I and II? _____

Answer: Autosomal dominant

Flashcard 537: If a disease has an autosomal recessive inheritance pattern, it usually _____ skip generations

Answer: does

Flashcard 538: What type of oncogene is cyclin D1?_____

Answer: cyclin (cell cycle regulator)

Flashcard 539: 1% of cases of Down syndrome are due to _____

Answer: mosaicism

Flashcard 540: Which pyrimidine is found in DNA only?_____

Answer: Thymine