Molecular Genetics US Medical PG Flashcards - Medical Study Cards
Master Molecular Genetics with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Molecular Genetics Flashcard Deck - 10 Cards
Flashcard 111: What is the mechanism that results in malignancy from the N-MYC oncogene?
_____
Answer: amplification
Extra:
https://onlinemeded.org/spa/endocrinology/adrenals/acquire?ref=anki
Flashcard 112: A(n) _____ occurs when the long arms of 2 acrocentric chromosomes fuse at the centromere and the 2 short arms are lost
Answer: Robertsonian translocation
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/mitosis-meiosis-and-the-cell-cycle?index=4]
https://onlinemeded.org/spa/genetics?ref=anki
Flashcard 113: _____ is a tumor suppressor that is a negative regulator of β-catenin and WNT pathway
Answer: APC
Extra:
* Gnome pulling carrot "A Pulled Carrot" - APC tumor suppressor gene
Watch Colorectal Polyps & Cancer [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-gi/videos/medical-pathophysiology-gi-colorectal-and-anal-disorders-colorectal-polyps-and-cancer?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/colorectal-pathology?index=9]
https://onlinemeded.org/spa/immunology?ref=anki
Flashcard 114: Gain of functions in the _____ oncogene result in chronic myeloproliferative disorders
Answer: JAK2
Extra:
Receptor associated tyrosine kinase (signals for things such as erythropoietin, thrombopoietin); hence there is activation of STATs
https://onlinemeded.org/spa/endocrinology?ref=anki
Flashcard 115: Microsatellites are repeating sequences of _____ DNA
Answer: non-coding
Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/colorectal-pathology?index=10]
https://onlinemeded.org?ref=anki
Colorectal carcinogenesis pathways
Top: Chromosomal instability pathway (adenoma-carcinoma sequence)
- Loss of the tumor suppressor gene, APC, results in hyperproliferative epithelium due to a loss of cellular adhesion and increased cellular proliferation. A mutation in KRAS results in unregulated cellular signaling and cellular proliferation, leading to the formation of an adenoma. Loss of the tumor suppressor genes TP53 and DCC results in the malignant transformation of an adenoma to carcinoma. The chromosomal instability pathway is responsible for carcinomas in FAP (loss of APC) as well as in most cases of sporadic colorectal carcinoma.
Bottom: Microsatellite instability pathway
- Acquired or inherited mutations in the mismatch repair genes (esp. MLH1 and MSH2) result in abnormal proliferation and the formation of adenoma and carcinoma. The microsatellite instability pathway is responsible for carcinomas in Lynch syndrome (HNPCC) and a few cases of sporadic colorectal carcinoma.
Flashcard 116: The _____ is a Y-shaped region along the DNA template where leading and lagging strands are synthesized
Answer: replication fork
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-replication-transcription-and-translation?index=2]
https://onlinemeded.org?ref=anki
Flashcard 117: α-thalassemia is usually due to gene _____
Answer: deletions
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/microcytic-anemia?index=16]
https://onlinemeded.org/spa/cirrhosis-iii-acute-decompensation?ref=anki
Atlas:
Other:
Flashcard 118: The _____ is the distribution center for proteins and lipids from the endoplasmic reticulum to the vesicles and plasma membrane
Answer: golgi apparatus
Extra:
https://onlinemeded.org?ref=anki
Flashcard 119: Which end of the DNA strand does the DNA primer bind to during PCR?
_____
Answer: 3' end
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/laboratory-techniques?index=2]
https://onlinemeded.org?ref=anki
Flashcard 120: _____ analysis analyzes DNA using variations in restriction enzyme sites between homologous DNA strands
Answer: RFLP
Extra:
https://onlinemeded.org?ref=anki
Keywords: Molecular Genetics flashcards, medical flashcards, NEET PG preparation, USMLE Step 1 flashcards, Anki alternative, spaced repetition medical, OnCourse flashcards
