Metabolism — Flashcards

A research develops an agent that specifically blocks interaction of inositol triphosphate with its intracellular receptor. -Compared to the control cells ,decreased activity of which enzyme is most likely to be observed in the experimental cells?

What are the followings in relation to biotin deficiency? -Glucose to ribose-5-phosphate -Pyruvate to acetyl-CoA -Pyruvate to alanine -Pyruvate to oxaloacetate -Succinate to oxaloacetate

What are the followings in relation to lesch-nyhan syndrome? -Aspartate carbamoyltransferase -Dihydroorotase -Hypoxanthine-guanine phosphoribosyltransferase -Phosphoribosyl pyrophosphate amidotransferase -Ribonucleotide reductase -Thymidylase synthase

A 6 month old boy ic brought to the office by his mother concerning he's not developing normally. -Physical exam: delayed developmental milestone & hypotonia. -He has tendency to aggressively bite his own lips and fingers. -Labs: Elevated blood uric acid level. -Activity of what enzymes is most likely increased as a result of this patient's symptoms?

What are the followings enzymes in relation to cathecolamine? -Cathecol-O-methyltransferase -Monoamine oxidase -Phenylethanolamine-N-Methyltransferase

22 y/o comes with 5 day history of Nausea, constipation, and severe, poorly localized abdominal pain. -She also reports anxiety, poor sleep quality and tingling of limbs. -She doesn't take any drugs,no smoking, medication or use alcohol. -Patient receives intravenous infusion of heme preparation that leads to rapid resolution of her symptoms. -The improvement in symptoms is most likely due to treatment-induced downregulation of what enzymes?

The followings compounds will serve as a precursor to what? -Arginine -Carotene -Cholesterol -Orotic acid -Phenylalanine -Tryptophan

A scientist is studying biochemical reaction that take place in the liver. -He cultures hepatocytes with glutamate labeled with nitrogen isotopes -After some times, he finds that the nitrogen isotopes are transferred to oxaloacetate forming aspartate. -Which vitamins is most likely involved in this reaction?

What are the followings in relation to vitamin deficiency? -Abnormal oxidative decarboxylation of ketoacids. -Abnormal proline hydroxylation -Abnormal transamination -deficient methionine synthesis -Diminished synthesis of purines

A study is being performed that includes certain men -Further analysis shows that these men have an X-linked mutation affecting the phosphoribosyl pyrophosphate (PRPP) synthetase gene. -This lead to increased substrate conversion. -What organ is most likely to develop pathology secondary to this mutation?