Metabolism — Flashcards

In what reaction the followings occurs? -Aconitase -Enolase -Glucose-6-phosphate dehydrogenase -Glutathione reductase -Transketolase

A 34 y/o man comes with fascial injury. -He reports getting hit on the face furing a fistfight at a bar. -Physical exam: Dark blue periorbital ecchymosis on the right side. -Ophthalmic & neurologic examinations are otherwise normal. -Patient is discharge home, but several day later the bruise becomes greenish in color. -This change in color is best explained by the activity of which enzymes?

What are these two end-product has in common? -Sorbitol -galacticol

18 y/o girl with type 1 DM comes with several hours of nausea, vomiting and abominal pain. -breath: fruity odor -Glucose: 452 & high anion gap metabolic acidosis. -Increased activity of what enzyme is most likely contributing to this patient's abnormal blood glucose finding?

What are the followings in relation to phosphorylation of mannose residues on glycoproteins? -Extracellular space -Lysosome -Mitochondria -Nucleus -Plasma membrane

Exposures to what cellular pathway will cause these substances to increase? -Ca2+ -cAMP -cGMP -Cl -mRNA -NO

1 day old boy is diagnosed with hyperphenylalanemia by newborn screening. -He's placed on a special phenylalanine-restricted diet with tyrosine supplementation. -Several months later, lab test results: normal serum phenylalanine level. -Careful examination: some neurological abnormalities. -Further workup: elevated prolactin. -Physician suspects a cofactor deficiency. -Which enzymes is most likely deficient in this patient?

A group of investigators is studying the regulation of catecholamines synthesis in response to severe stress. -The experimental animals are found subsequently to have decreased production of epinephrine by the adrenal medulla compared with the control animals. -Decreased activity of which enzymes is most likely responsible for the observed effect?

23 y/o apparently healthy man who immigrated to the US comes to a clinic for regular check up. -History: no significant mediacl problems but his mother told him he was bron with problem metabolizing sugar. -Patient maintains no dietary restrictions and regularly eats vegetable, fruits meats. -Urine samples: Repeatedly positive copper reduction test. -Glucose oxidase dipstick test: negative -Which enzyme is most likely to be deficient in this patient?

The followings conversion pathways are most likely deficent in what disease? -Leucine to acetoacetate -Phenylalanine to tyrosine -Tyrosine to fumarate