DNA repair US Medical PG Flashcards - Medical Study Cards
Master DNA repair with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
DNA repair Flashcard Deck - 10 Cards
Flashcard 31: Xeroderma Pigmentosum is inherited in a(n) _____ fashion
Answer: autosomal recessive
Extra:
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Flashcard 32: What form of DNA repair fixes mutations induced by UV radiation?_____
Answer: nucleotide excision repair
Flashcard 33: What phase of the cell cycle do base excision repairs occur?_____
Answer: Throughout the cell cycle
Flashcard 34: In base excision repair, which enzyme is responsible for cleaving the 5' end of the AP site?
Answer: AP-endonuclease
Extra: Base excision repair sequence:
1. DNA glycosylase removes the damaged base (leaving an AP site).
2. **AP-endonuclease** cleaves the 5' end.
3. **Lyase** cleaves the 3' end.
4. DNA polymerase-$\beta$ fills the gap.
5. DNA ligase seals the nick.
Flashcard 35: What phase of the cell cycle do nucleotide excision repairs occur?_____
Answer: G1
Flashcard 36: The _____ is involved in regulating Homologous Recombination, and when mutated causes Bloom syndrome
Answer: BLM helicase
Flashcard 37: What form of DNA repair fixes mutations due to spontaneous/toxic deamination?_____
Answer: Base excision repair
Flashcard 38: Is Nonhomologous End Joining error prone?_____
Answer: Yes
Flashcard 39: The enzyme that recognizes and excises pyrimidine dimer mutations is _____
Answer: excision endonuclease
Flashcard 40: When using CRISPR/Cas9 that introduce a double strand break to knock-out target DNA, _____ repair the gap introduced by this Cas9 variant
Answer: nonhomologous end joining enzymes
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