DNA repair US Medical PG Flashcards - Medical Study Cards
Master DNA repair with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
DNA repair Flashcard Deck - 10 Cards
Flashcard 1: What are the four mechanisms of DNA repair?
Answer: Nuceotide excision repair
Base excision repair
Mismatch repair
Nonhomologous end joining
Flashcard 2: non-homologous end joining
Answer: join 2 dsDNA ends
Extra: double-stranded breaks (when no homologous chromosome is around to use as a guide) ataxia telangiectasia
Flashcard 3: mismatch repair
Answer: 1. new strand recognized (lacks methylation)
2. mismatched nucleotides removed
3. DNA pol/ligase fills/seals gap
Extra: Mismatched bases on newly synthesized DNA strand hereditary nonpolyposis colorectal cancer (HNPCC)
Flashcard 4: base excision repair (BER)
Answer: 1. specific glycosylases recognize and remove damaged bases
2. AP endonuclease removes AP DNA
3. DNA pol/ligase fill/seal gap
Extra: spontaneous/toxic changes to the base itself; most often deamination
Flashcard 5: nucleotide excision repair (NER)
Answer: 1. endonuclease removes short ssDNA segment containing lesion
2. DNA pol/ligase fill/seal gap
Extra: bulky adducts, commonly thymine dimers caused by UV radiation xeroderma pigmentosa
Flashcard 6: Is homologous recombination error prone?
_____
Answer: No
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-mutations-damage-and-repair?index=6]
https://onlinemeded.org?ref=anki
Flashcard 7: BRCA1 and BRCA2 are tumor suppresors that are involved in mediating the _____ pathway of DNA repair
Answer: Homologous Recombination
Extra:
Watch Pancreatic Cancer & Islet Cell Tumors [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-neuro/videos/medical-pathophysiology-neuro-intracranial-hypertension-and-tumors-adult-cns-tumors?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/pathology/videos/cellular-injury-and-neoplasia?index=10]
https://onlinemeded.org?ref=anki
Flashcard 8: Chronic exposure to Aflatoxins may cause cancer by causing a(n) G:C --> T:A transversion in codon 249 of the _____ gene
Answer: TP53
Extra:
https://onlinemeded.org/spa/immunology?ref=anki
Flashcard 9: Aplastic anemia may be caused by Fanconi anemia, which occurs due to a(n) _____ defect, resulting in bone marrow failure
Answer: dsDNA repair
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/normocytic-anemia?index=10]
https://onlinemeded.org?ref=anki
Atlas:
Other:
Flashcard 10: Mechanisms to repair _____ breaks are defective in Ataxia telangiectasia, Fanconi anemia, and SCID
Answer: dsDNA
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-mutations-damage-and-repair?index=4]
https://onlinemeded.org/spa/immunology?ref=anki
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