Rheumatology & Haematology — Flashcards

Secondary polycythaemia is characterised by _____ O2 saturation %

What is the likely diagnosis in a patient with night sweats, weight loss, and splenomegaly? Laboratory exam reveals leucocytosis with increased levels of basophils and myelocytes. _____

Hint: diagnosis?

What is the management for polycythaemia vera? _____

Hint: 2

Chronic myeloid leukaemia may transform to acute _____ leukaemia (2/3rd of cases) Chronic myeloid leukaemia may transform to acute lymphoblastic leukaemia (1/3rd of cases)

The t(_____;22) translocation generates a(n) BCR-ABL fusion protein with increased tyrosine kinase activity in chronic myeloid leukaemia

What phases does chronic myeloid leukaemia present in? _____ → Accelerated phase → Blast crisis / phase

_____ are a group of disorders characterised by abnormal proliferation of normally developed stem cells of the myeloid cell lineage

What is the most common cause of morbidity in polycythaemia vera? _____

Chronic myeloid leukaemia is distinguished from a leukemoid reaction (benign neutrophilia) by a(n) -ve _____ stain

A rapidly enlarging _____ in chronic myeloid leukemia (CML) suggests progression from accelerated phase to blast crisis