Rheumatology & Haematology — Flashcards

Flashcard 411: Polycythaemia vera is a form of _____ polycythemia

Answer: primary

Flashcard 412: Chronic myeloid leukaemia is often diagnosed _____ on a FBC

Answer: incidentally

Flashcard 413: The t(9;22) translocation (BCR-ABL) is also known as the _____ chromosome most commonly seen in chronic myeloid leukaemia (CML)

Answer: Philadelphia

Flashcard 414: A rapidly enlarging _____ in chronic myeloid leukemia (CML) suggests progression from accelerated phase to blast crisis

Answer: spleen

Flashcard 415: What is the management of chronic myeloid leukaemia (CML) in the blastic crisis? _____

Answer: Tyrosine kinase inhibitors (TKI) + Induction chemotherapy + Allogeneic hematopoietic stem cell transplant

Extra: Blastic crisis is managed similarly to acute leukemia. Treatment involves a combination of high-dose TKIs (like dasatinib) and induction chemotherapy to return the patient to a second chronic phase, followed by an allogeneic stem cell transplant, which is the only curative option.

Flashcard 416: Polycythaemia vera is variable but typically occurs in ages >_____ years

Answer: 60

Flashcard 417: Chronic myeloid leukemia is usually insidious in onset and seen in _____

Answer: older adults

Flashcard 418: How does _____ affect cells? ↑ thrombocytes

Answer: essential thrombocythaemia

Flashcard 419: Chronic myeloid leukaemia is a _____ disorder

Answer: myeloproliferative

Flashcard 420: _____ is a myeloproliferative disorder causing a neoplastic proliferation of mature myeloid cells, especially red blood cells

Answer: Polycythaemia vera