Rheumatology & Haematology UK Medical PG Flashcards - Medical Study Cards
Master Rheumatology & Haematology with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Rheumatology & Haematology Flashcard Deck - 10 Cards
Flashcard 371: How does myelofibrosis lead to massive splenomegaly (pathophysiology)?
_____
Answer: Proliferation of megakaryocytes that activate fibroblasts → fibrosis of bone marrow → erythropoiesis is impaired → extramedullary haematopoiesis (esp. spleen & liver) → hepatosplenomegaly
Flashcard 372: What is the definitive management of myelofibrosis?
_____
Answer: Haematopoietic stem cell transplant
Flashcard 373: What hypersensitivity reaction is allergic transfusion reaction?
_____
Answer: Type I HSR
Flashcard 374: What are the initial investigations for myelofibrosis?
_____
Answer: FBC & blood smear
Flashcard 375: What is the management of acute haemolytic transfusion reactions?
_____
Answer: Stop transfusion, aggressive IV fluids
Flashcard 376: What vital sign helps distinguish between TACO and TRALI?
_____
Answer: TACO is fluid overload → hypertension
TRALI is fluid shift into lungs → hypotension
Flashcard 377: Which blood transfusion reaction is caused by antibodies against minor antigens (e.g. Rh(D) antigen) leading to extravascular haemolysis?
_____
Answer: Delayed haemoltyic transfusion reaction
Flashcard 378: Patients with selective IgA deficiency should receive _____ blood products to prevent anaphylaxis
Answer: washed
Flashcard 379: What is the management of febrile non-haemolytic transfusion reactions?
_____
Answer: Stop/slow transfusion, IV paracetamol
Flashcard 380: Which blood transfusion reaction is caused by donor anti-leukocyte antibodies against recipient neutrophils and pulmonary endothelial cells?
_____
Answer: Transfusion-related acute lung injury (TRALI)
Keywords: Rheumatology & Haematology flashcards, medical flashcards, NEET PG preparation, USMLE Step 1 flashcards, Anki alternative, spaced repetition medical, OnCourse flashcards