Rheumatology & Haematology UK Medical PG Flashcards - Medical Study Cards
Master Rheumatology & Haematology with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Rheumatology & Haematology Flashcard Deck - 10 Cards
Flashcard 361: What physical exam finding can distinguish myelofibrosis from aplastic anemia?
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Answer: Hepatosplenomegaly
Flashcard 362: What is the management of anaphylactic transfusion reaction?
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Answer: Stop transfusion, IM adrenaline, ABC support (O2, fluids)
Flashcard 363: Delayed transfusion haemolytic transfusion reaction has +ve _____ test
Answer: direct antiglobulin (Coombs)
Flashcard 364: Myelofibrosis can present with _____ splenomegaly
Answer: symptomatic
Flashcard 365: What are the examination finding(s) of myelofibrosis?
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Answer: Massive splenomegaly + hepatomegaly
Flashcard 366: How does myelofibrosis lead to massive splenomegaly (pathophysiology)?
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Answer: Proliferation of megakaryocytes that activate fibroblasts → fibrosis of bone marrow → erythropoiesis is impaired → extramedullary haematopoiesis (esp. spleen & liver) → hepatosplenomegaly
Flashcard 367: Which blood transfusion reaction can be caused by accumulation of cytokines from donor WBC
-or-
type II HSR with host antibodies against donor HLA/WBCs?
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Answer: Febrile nonhemolytic transfusion reaction (FNHTR)
Flashcard 368: What pathologic RBC is associated with myelofibrosis?
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Answer: "Tear drop" cells (dacrocyte)
Flashcard 369: What distinguishing symptom is seen in acute haemolytic transfusion reaction?
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Answer: Haemoglobinuria (due to a massive release of Hb)
Flashcard 370: What hypersensitivity reaction is allergic transfusion reaction?
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Answer: Type I HSR
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