Rheumatology & Haematology — Flashcards

In sickle cell disease antibiotic prophylaxis with _____ is given at ages >3months until 5 years old (or lifelong)

hydroxycarbamide(hydroxyurea) is useful in the treatment of sickle cell disease because it increases ↑ levels of _____ (typically >15%)

The most important management in aplastic crisis is _____

What RBC pathology is characterized by the following Hb electrophoresis findings: 55% HbA, 43% HbS, and 2% HbA2 _____

Newborn babies are screened for sickle cell disease on _____ with the newborn blood spot screening programme (heel prick test)

Hint: timing

_____ is a possible feature of sickle cell disease that involves acute & reversible reticulocytopaenia

_____ is considered in severe vaso-occlusive crisis/events, e.g. acute chest syndrome or stroke

Hint: Management

What RBC pathology is characterised by the following Hb electrophoresis findings: 90% HbS, 8% HbF, and 2% HbA2 (no HbA) _____

Sickle cell disease can cause _____ that involves splenic vaso-occlusion and pooling of large amounts of blood in the spleen

Patients with sickle cell disease are given _____ to prevent infection with encapsulated organisms