T1DM is associated with the genetic variants _____ and HLA-DR4
DKA primarily affects patients with _____, but can rarely affect patients with type 2 diabetes
Which of the following are clinical features typically found in DKA but **not** in HHS?\n\n• _____\n• Hyperventilation/Kussmaul breathing\n• Pear drop breath (acetone)
There is no specific criteria, but HHS typically presents with: • Serum glucose: _____ mmol/L • Serum osmolarity: significantly raised • Ketones: Normal (<3 mmol/L) • pH: Normal (>7.3)
_____ is the most important electrolyte to consider in DKA. DKA causes an intracellular deficit of potassium
_____ and short acting insulins have a quick onset and short duration. They are used to replicate insulin spikes in response to glucose from a meal or sugar\nIntermediate and long acting insulins have a slow onset and long duration. They are used to replicate endogenous basal insulin secreted continuously throughout the day
HHS is caused by insufficient _____ which may be precipitated by illness or medications
HHS pathophysiology is predominantely characterised by severe _____
_____ is much more profound in HHS due to later presentation
Hint: Clinical feature
Insulin therapy for HHS SHOULD NOT begin until _____ UNLESS there is significant ketonemia (or DKA).
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