Endocrinology & Diabetes — Flashcards

Flashcard 381: Cortisol raises serum glucose by stimulating _____

Answer: gluconeogenesis

Flashcard 382: Loss of libido and body hair in Addison's disease are features of _____

Answer: hypoandrogenism

Flashcard 383: _____ replacement is not required in the management of secondary/tertiary adrenal insufficiency because aldosterone production is maintained by the Renin-Angiotensin System

Answer: Mineralocorticoid

Extra: In secondary/tertiary adrenal insufficiency, the defect is in ACTH production. While cortisol (Glucocorticoid) depends on ACTH, aldosterone (Mineralocorticoid) is primarily regulated by the Renin-Angiotensin-Aldosterone System (RAAS) and potassium levels, which remain intact.

Flashcard 384: A patient has no increase of serum cortisol 30 minutes after being given Synacthen 250ug IM, what is the most likely diagnosis? _____

Answer: Primary adrenal insufficiency (Addison's disease)

Flashcard 385: The management of addisonian crisis is with immediate _____ followed by 1L normal saline over 30-60 minutes

Answer: Hydrocortisone 100mg IM/IV

Flashcard 386: The most common infectious cause of Addison's disease is _____

Answer: Tuberculosis

Flashcard 387: _____ adrenal insufficiency is caused by conditions that decrease CRH production

Answer: Tertiary

Flashcard 388: _____cortisone is not required in the management of addisonian crisis because hydrocortisone exerts weak mineralocorticoid action

Answer: Fludro

Flashcard 389: Diagnosis of addisonian crisis is based on _____

Answer: clinical suspicion

Flashcard 390: Sick day rules must be followed for Addison's disease in order to prevent _____

Answer: addisonian crisis