Respiratory System Drugs — Flashcards

Flashcard 41: Zileuton, montelukast, and zafirlukast are all associated with rare cases of _____ dysfunction.

Answer: hepatic

Flashcard 42: _____ is a systemic steroid used for maintenance therapy after an acute exacerbation of asthma.

Answer: Prednisolone

Flashcard 43: Leukotrienes are _____ potent than histamine in increasing vascular permeability and causing bronchospasm.

Answer: more

Flashcard 44: Thiopentone does not completely supress airway response to laryngoscopy and may lead to _____ in asthmatics

Answer: bronchospasm

Flashcard 45: _____ is the major prostaglandin produced by mast cells.

Answer: PGD2

Flashcard 46: _____ is a PGF2alpha agonist and is contraindicated in women with asthma as it worsens air way resistance

Answer: Carboprost

Flashcard 47: What is the management of choice for moderate persistent asthma?

Answer: Low-dose ICS + LABA (plus SABA as needed)

Extra: According to NAEPP and GINA guidelines: - **Step 3 (Moderate Persistent):** Low-dose ICS + LABA. - **Current GINA Preferred (Track 1):** Maintenance and Reliever Therapy (MART/SMART) using low-dose ICS-formoterol.

Flashcard 48: What is the ideal drug management of severe persistent asthma not resolving despite treatment?_____

Answer: high dose ICS + LABA + oral steroids + add-on therapy

Flashcard 49: What is the drug management of mild persistent asthma (Step 2)?

Answer: Preferred: As-needed low-dose ICS-formoterol Alternative: Daily low-dose ICS + as-needed SABA

Extra: Mild persistent asthma corresponds to GINA Step 2. In modern guidelines, the preferred approach is using a combination of low-dose ICS and formoterol as needed. The alternative is regular maintenance therapy with a low-dose ICS plus a SABA for symptom relief.

Flashcard 50: Paradoxical bronchoconstriction with ipratropium bromide is seen with a _____tonic nebulizer solution

Answer: hypo