Respiratory System Drugs Indian Medical PG Flashcards - Medical Study Cards
Master Respiratory System Drugs with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Respiratory System Drugs Flashcard Deck - 61 Cards
Flashcard 1: Ipratropium is a competitive _____ receptor antagonist that is used to prevent bronchoconstriction in asthmatic and COPD patients
Answer: M3
Flashcard 2: In the treatment of Cystic Fibrosis, _____ works by facilitating proper folding of the CFTR protein
Answer: Lumacaftor
Flashcard 3: Corticosteroids treat asthma by blocking _____ and cellular infiltration
Answer: inflammation
Flashcard 4: _____ is a monoclonal antibody against IL-5 receptor alpha used for maintenance therapy for asthma.
Answer: Benralizumab
Flashcard 5: Dextromethorphan is an antitussive that has mild _____ effects when used in excess and thus has mild abuse potential
Answer: opioid
Flashcard 6: Salmeterol and formoterol are _____-acting 2 agonists
Answer: long
Flashcard 7: Leukotrienes _____, D4 and E4 increase airway vascular permeability, mucus production, and bronchoconstriction (bronchospasm)
Answer: C4
Flashcard 8: Inhaled _____ inactivate NF-B, the transcription factor that induces production of TNF- and other inflammatory agents
Answer: corticosteroids
Flashcard 9: _____ route is preferred over the intravenous route in acute severe asthma as it is easier and safer with equivalent efficacy.
Answer: Nebulized
Flashcard 10: First Aid Pharmacology: Respiratory Pseudoephedrine and phenylephrine are _____ agonists that may be used as nasal decongestants
Answer: -adrenergic
Flashcard 11: Diphenhydramine and meclizine (1st generation H1 receptor blockers) may cause significant _____ and have significant anti-muscarinic properties
Answer: sedation
Flashcard 12: Ipratropium and tiotropium primarily affect the _____ (organ) via inhibition of M3 muscarinic receptors
Answer: lungs
Flashcard 13: Dornase Alfa works by cleaving _____ present in the mucus of Cystic Fibrosis patients thus reducing the visocity of lung secretions
Answer: DNA
Flashcard 14: Adverse effects of non-selective -blockers include exacerbation of _____ and COPD
Answer: asthma
Flashcard 15: First Aid Pharmacology: Respiratory _____ is a synthetic codeine analog that is used clinically as an anti-tussive
Answer: Dextromethorphan
Flashcard 16: First Aid Pharmacology: Respiratory Guaifenesin is an _____ that thins respiratory secretions
Answer: expectorant
Flashcard 17: Anti-muscarinics may be used to _____ bronchial airways and reduce secretions
Answer: dilate
Flashcard 18: Respiratory (Asthma) _____-acting 2 agonists (e.g. albuterol) are administered as metered-dose inhalers for acute relief of symptoms
Answer: Short
Flashcard 19: _____ and Nedocromil prevent mast cell degranulation (used for asthma prophylaxis)
Answer: Cromolyn sodium
Flashcard 20: Theophylline causes broncho-_____ by inhibiting phosphodiesterase
Answer: dilation
Flashcard 21: _____ is contraindicated in active smokers, asthmatics and COPD patients
Answer: Afrezza
Flashcard 22: First Aid Pharmacology: Respiratory _____ is a mucolytic agent that liquifies mucus by disrupting disulfide bonds; useful in Chronic Bronchitis / COPD and Cystic Fibrosis patients
Answer: N-acetylcysteine
Flashcard 23: Which classes of drugs are used to treat asthma by blocking inflammation (late response)? _____, anti-leukotrienes
Answer: Inhaled corticosteroids
Flashcard 24: Which classes of drugs are used to treat asthma by blocking bronchoconstriction (early response)? _____, theophylline (methylxanthines), muscarinic antagonists
Answer: 2 agonists
Flashcard 25: Respiratory Adverse effects associated with pseudoephedrine include - _____ stimulation- anxiety (mood altering)
Answer: CNS
Flashcard 26: In the treatment of Cystic Fibrosis, _____ works by stimulating activity of the CFTR protein
Answer: Ivacaftor
Flashcard 27: Asthma _____ is a monoclonal antibody directed against the Fc portion of IgE, preventing mast cell sensitization
Answer: Omalizumab
Flashcard 28: _____ is a thromboxane receptor antagonist used in prophylaxis of asthma
Answer: Seratrodast
Flashcard 29: First Aid Pharmacology: Respiratory (Asthma) _____ cAMP causes broncho-dilation
Answer: Increased
Flashcard 30: Albuterol, pirbuterol, and metaproterenol are _____-acting 2 agonists
Answer: short
Flashcard 31: Respiratory Pseudoephedrine and phenylephrine may be used clinically to reduce - _____- edema- nasal congestion
Answer: hyperemia
Flashcard 32: First Aid Pharmacology: Respiratory _____ is an anti-tussive that exerts its effects via antagonism of the NMDA glutamate receptor
Answer: Dextromethorphan
Flashcard 33: What is recommended as regular therapy for the prevention of symptoms of exercise-induced asthma?_____
Answer: Inhaled corticosteroids
Flashcard 34: What is the ideal drug management of severe persistent asthma?_____
Answer: medium dose ICS + LABA + add-on therapy
Flashcard 35: What is the ideal drug management of mild intermittent asthma?_____
Answer: As needed SABA low dose ICS
Flashcard 36: Churg-Strauss syndrome consisting of vasculitis with eosinophilia is associated with the use of which anti-asthma drugs?_____
Answer: montelukast and zafirlukast.
Flashcard 37: Rhinitis medicamentosa is due to prolonged use of _____.*treatment?
Answer: nasal decongestants (medication)
Flashcard 38: Revafenacin is the anticholinergic agent useful for _____
Answer: COPD
Flashcard 39: Ipratropium is a _____-acting muscarinic antagonist.
Answer: short
Flashcard 40: Indacaterol, Olodaterol and Vilanterol belong to the category of _____ acting beta 2 agonists
Answer: very-long
Flashcard 41: Zileuton, montelukast, and zafirlukast are all associated with rare cases of _____ dysfunction.
Answer: hepatic
Flashcard 42: _____ is a systemic steroid used for maintenance therapy after an acute exacerbation of asthma.
Answer: Prednisolone
Flashcard 43: Thiopentone does not completely supress airway response to laryngoscopy and may lead to _____ in asthmatics
Answer: bronchospasm
Flashcard 44: Leukotrienes are _____ potent than histamine in increasing vascular permeability and causing bronchospasm.
Answer: more
Flashcard 45: _____ is the major prostaglandin produced by mast cells.
Answer: PGD2
Flashcard 46: _____ is a PGF2alpha agonist and is contraindicated in women with asthma as it worsens air way resistance
Answer: Carboprost
Flashcard 47: What is the ideal drug management of moderate persistent asthma?_____
Answer: As needed SABA +low dose ICS + daily low dose ICS +LABA
Flashcard 48: What is the ideal drug management of severe persistent asthma not resolving despite treatment?_____
Answer: high dose ICS + LABA + oral steroids + add-on therapy
Flashcard 49: What is the ideal drug management of mild persistent asthma?_____
Answer: As needed SABA + low dose ICS + daily low dose ICS
Flashcard 50: _____ is a TGF- inhibitor used to slow down progression of lung fibrosis
Answer: Pirfenidone
Flashcard 51: Paradoxical bronchoconstriction with ipratropium bromide is seen with a _____tonic nebulizer solution
Answer: hypo
Flashcard 52: _____ and Pirfenidone are antifibrotic agents useful in management of Idiopathic pulmonary fibrosis
Answer: Nintedanib
Flashcard 53: _____ for PPH is contraindicated in bronchial asthma patients
Answer: Carboprost
Flashcard 54: As per GINA guidelines, _____ + low-dose ICS is the preferred reliever in all cases of asthma irrespective of the severity of the disease.
Answer: formoterol
Flashcard 55: Systemic _____ is the most appropriate drug for the treatment of ABPA.
Answer: corticosteroids
Flashcard 56: _____-blocking drugs may be used in refractory asthma with high eosinophil count
Answer: IL-5
Flashcard 57: Drug of choice for acute severe asthma is:
Answer: Salbutamol
Flashcard 58: Drug of choice for acute excacerbation of bronchial asthma -
Answer: Short-acting beta-2 agonists (SABAs)
Flashcard 59: Drug of choice for Hay fever:
Answer: Intranasal corticosteroids
Flashcard 60: Drug of choice for Type 1 Brittle asthma is
Answer: Subcutaneous salbutamol
Flashcard 61: Drug of choice for treatment of acute asthmatic attacks is :
Answer: Salbutamol
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