Autonomic Nervous System Drugs — Flashcards

Flashcard 71: _____ is a Rho kinase (ROCK) inhibitor that is approved for lowering Intraocular pressure in patients with open-angle glaucoma or ocular hypertension

Answer: Netarsudil

Flashcard 72: _____ is a non-selective, reversible alpha-1 and alpha-2 adrenergic receptor antagonist.

Answer: Phentolamine

Flashcard 73: Which cholinomimetic is used to treat post-operative and neurogenic ileus?

Answer: Bethanechol

Flashcard 74: _____ generation H1 receptor antagonists (antihistamines) may cause dizziness and hypotension due to anti-alpha-1 adrenergic effects.

Answer: 1st

Extra: 1st generation antihistamines (e.g., diphenhydramine, promethazine, hydroxyzine) have several off-target effects: - **Anti-alpha-1**: Hypotension, dizziness (orthostatic) - **Anti-muscarinic**: Dry mouth, urinary retention, blurred vision (atropine-like) - **Anti-serotonergic**: Weight gain/increased appetite - **H1 blockade (CNS)**: Sedation/drowsiness

Flashcard 75: The _____ adrenergic receptor is coupled to Gq

Answer: alpha-1

Flashcard 76: Treating an organophosphate poisoning is two fold; _____ which inhibits all subtypes of muscarinic receptors, and Pralidoxime, which if given early - regenerates AChE

Answer: Atropine

Flashcard 77: Isoproterenol acts on _____ and $\beta_2$ adrenergic receptors

Answer: $\beta_1$

Flashcard 78: Terbutaline and ritodrine are _____ receptor agonists that are used to relax uterine smooth muscle

Answer: beta-2

Flashcard 79: _____ are a type of acetylcholinesterase inhibitor found in many insecticides

Answer: Organophosphates

Flashcard 80: Activation of the _____ adrenergic receptor causes decreased levels of intracellular cAMP

Answer: alpha-2