Liver and Biliary Pathology — Flashcards

Flashcard 51: Perisinusoidal ('chicken-wire') fibrosis is more prominent in _____

Answer: Alcoholic and non-alcoholic steatohepatitis (ASH/NASH)

Extra: In contrast, portal-based fibrosis is the typical pattern seen in chronic viral hepatitis. ASH and NASH are characterized by perisinusoidal/pericellular ("chicken-wire") fibrosis starting in zone 3.

Flashcard 52: Low tumor stage in hepatoblastoma is associated with a _____ prognosis

Answer: good

Flashcard 53: Budd-chiari syndrome will lead to _____nodular cirrhosis

Answer: micro

Flashcard 54: Bile duct proliferation is seen in _____ on liver biopsy

Answer: Extrahepatic biliary atresia (EHBA)

Extra: Bile duct proliferation is a key histological feature used to differentiate Extrahepatic Biliary Atresia (EHBA) from neonatal hepatitis (where duct proliferation is typically absent).

Flashcard 55: Which form of cholangiocarcinoma is associated with favourable outcomes?_____

Answer: Papillary

Flashcard 56: A patient of Alagille syndrome will show _____ number of interlobular bile ducts on liver biopsy

Answer: reduced

Flashcard 57: Rhabdoid features in hepatoblastoma is associated with a _____ prognosis

Answer: poor

Flashcard 58: Interface hepatitis and ductular reaction are a feature of _____ hepatitis

Answer: chronic (acute/chronic)

Flashcard 59: Inflammation is more prominent, with neutrophils in _____

Answer: alcoholic liver disease (ALD/NASH)

Flashcard 60: Fibrolamellar variant of hepatocellular carcinoma (HCC) is likely to be associated with elevated levels of _____

Answer: neurotensin