Liver and Biliary Pathology — Flashcards

Flashcard 31: _____ cholangitis causes periductal fibrosis with an 'onion-skin' appearance histologically

Answer: Primary sclerosing

Flashcard 32: In growth factor phase of hepatocyte regeneration, _____ and TGF-α act on primed hepatocytes to stimulate cell metabolism and entry into the cell cycle

Answer: HGF

Flashcard 33: _____ is associated with anti-mitochondrial antibody

Answer: Primary biliary cirrhosis (PBC)

Flashcard 34: Histological imaging of hepatic adenoma shows cords of _____ containing excessive glycogen and fat

Answer: benign hepatocytes

Flashcard 35: Idiopathic non-cirrhotic portal hypertension (INCPH) is a rare disease characterized by intrahepatic portal hypertension due to peri_____ and perisinusoidal fibrosis

Answer: portal

Flashcard 36: Activation of _____ and inactivation of p53 are the two most common mutational events in hepatocellular carcinoma

Answer: β-catenin

Flashcard 37: All affected individuals of _____PKD have some degree of congenital hepatic fibrosis.

Answer: AR

Flashcard 38: Which two viruses can present with councilman bodies on liver biopsy? _____

Answer: HAV and Yellow fever virus

Extra: Councilman bodies are acidophilic (eosinophilic) globules representing apoptotic hepatocytes. They are classically seen in **Yellow fever** and **acute viral hepatitis** (e.g., Hepatitis A).

Flashcard 39: Autosomal _____ PKD is associated with congenital hepatic fibrosis which may lead to portal hypertension

Answer: recessive

Flashcard 40: Alcoholic _____ is characterized by swelling of hepatocytes with necrosis and neutrophilic infiltration

Answer: hepatitis