Inflammation and Repair — Flashcards

Swelling in inflammation is mediated by endothelial cell disruption (due to tissue damage) and endothelial cell contraction (caused by _____, histamine, and serotonin)

In the setting of chronic inflammation, macrophages can be activated to M2 macrophages by stimulation from _____ cells, resulting in a antiinflammatory phenotype

Rheumatoid arthritis is associated with _____, which are areas of fibrinoid necrosis with palisading histiocytes in the skin and visceral organs (e.g. lung)

Necroptosis involves 2 unique kinases called _____ and 3

Granulomas due to sarcoidosis often have characteristic _____-shaped inclusions ('asteroid bodies') within giant cells

The key mediators of redness and warmth in inflammation are _____, prostaglandins, and bradykinin

Integrin expression is upregulated on leukocytes by _____ and LTB4

Berylliosis is characterized by a _____ histology and therefore is occasionally responsive to treatment with steroids

The pathogenesis of Gout/Pseudogout involves Pattern Recognition Receptors detecting _____ in joints, which in response leads to an inflammatory cascade mediated by IL-1, causing the joint to be invaded by neutrophils

_____ and serotonin are among the first mediators to be released during inflammation