Bone and Soft Tissue Pathology — Flashcards

Flashcard 41: Ewings sarcoma are _____ positive (owing to intracellular glycogen) and reticulin negative

Answer: periodic acid schiff (PAS)

Flashcard 42: When chronically _____, PTH has catabolic effects on bone, known as osteitis fibrosa cystica.

Answer: elevated

Flashcard 43: Garre's sclerosing osteomyelitis is caused by a _____-grade anaerobic infection which is effectively contained by the host immune system

Answer: low

Flashcard 44: _____ is a mild autosomal dominant form of osteopetrosis that is caused by a mutation of CLCN7 gene

Answer: Albers-Schonberg disease

Flashcard 45: Spindle cells of aneurysmal bone cyst frequently demonstrate rearrangements of chromosome _____, leading to USP6 overexpression

Answer: 17p13

Flashcard 46: Stickler syndrome is due to defect in type _____ collagen

Answer: II

Flashcard 47: _____ is a self-limited fibroblastic and myofibroblastic proliferation arising in deep dermis, subcutis or muscle that typically occurs following trauma

Answer: Nodular fasciitis

Flashcard 48: Desmoid tumor commonly affects males _____ than females

Answer: less

Flashcard 49: On histology, a gradient of maturation (zonation) from cellular, loose, and myxoid to organized and fibrous is typical of _____ fasciitis

Answer: nodular

Flashcard 50: What is the earliest pathological change seen in osteoarthritis?

Answer: Fibrillation of the articular cartilage

Extra: The earliest biochemical changes in osteoarthritis are increased water content and decreased proteoglycans. This leads to the earliest morphological (pathological) change, known as fibrillation (cracking and splitting of the superficial layers of cartilage).