Rheumatology and Immunology — Flashcards

Flashcard 1: _____ scleritis _____ inflammation is seen in long standing cases of rheumatoid arthritis

Answer: Necrotizing

Flashcard 2: This image is an example of a "_____" deformity, which is most commonly associated with Rheumatoid arthritis

Answer: swan neck

Flashcard 3: caplan syndrome includes _____

Answer: rheumatoid arthritis + pneumoconiosis

Extra: 

Flashcard 4: Serum sickness-like reactions are associated with some drugs acting as _____ and infections (ex. HBV)

Answer: haptens (ex. penicillin)

Flashcard 5: Polymyositis and dermatomyositis may have ANA, _____, anti-Mi-2, and/or anti-SRP antibodies

Answer: anti-Jo-1

Flashcard 6: Ankylosing spondylitis can cause _____ lung disease due to limited chest wall expansion

Answer: restrictive

Flashcard 7: Common variable immunodeficiency is associated with increased risk for _____ disease and lymphoma *also associated with?[2]

Answer: autoimmune

Flashcard 8: Reactive arthritis classically arises in young adults after a _____ tract or Chlamydia trachomatis infection

Answer: GI

Flashcard 9: Patients with _____ deficiency may develop anaphylaxis to IgA-containing products (e.g. blood transfusions, gammaglobulins)

Answer: IgA

Flashcard 10: What HLA subtypes are associated with SLE? _____ and DR3

Answer: DR2

Flashcard 11: _____ syndrome is an autoimmune destruction of lacrimal and salivary glands

Answer: Sjogren

Flashcard 12: Cryoglobulinemic vasculitis is a _____ vessel vasculitis that can be seen in patients with HCV

Answer: small

Flashcard 13: Antibodies to spliceosomal snRNPs, also known as _____ antibodies, are highly specific for SLE

Answer: anti-Smith

Flashcard 14: _____ arteritis is associated with a weak or absent pulse in the upper extremity

Answer: Takayasu

Flashcard 15: _____-myositis is associated with increased risk for occult malignancy

Answer: Dermato

Flashcard 16: _____ transplant rejection can be prevented/reversed with immunosuppressants

Answer: Acute

Flashcard 17: _____ antibody is specific for rheumatoid arthritis

Answer: Anti-cyclic citrullinated peptide (anti-CCP)

Flashcard 18: Polyarteritis nodosa may present with _____ pain and melena due to involvement of the mesenteric artery

Answer: abdominal

Flashcard 19: The seronegative spondyloarthropathies may be remembered with the mnemonic "PAIR" P: _____A: Ankylosing spondylitisI: Inflammatory bowel diseaseR: Reactive arthritis

Answer: Psoriatic arthritis

Flashcard 20: Macrophage activation syndrome presents with _____triglyceridemia and extreme hyperferritinemia

Answer: hyper

Flashcard 21: Diffuse scleroderma is associated with _____ and anti-RNA Polymerase III antibodies

Answer: anti-Scl-70 (DNA topoisomerase I)

Flashcard 22: Limited scleroderma is also referred to as "CREST syndrome": C: _____R: Raynaud phenomenon E: Esophageal dysmotilityS: Sclerodactyly (thick, tight skin)T: Telangiectasias

Answer: Calcinosis cutis (and anti-Centromere Abs)

Flashcard 23: Rheumatoid arthritis may present with _____ finger deviation and radial wrist deviation

Answer: ulnar

Flashcard 24: Macrophage activation syndrome presents with a _____ in ESR due to hypofibrinogenemia

Answer: fall

Flashcard 25: _____ is caused by deposition of monosodium urate (MSU) crystals in tissues, especially the joints

Answer: Gout

Flashcard 26: _____ syndrome is an autoimmune disease that is associated with exposure to hydrocarbon solvents (e.g. dry-cleaning, paints, dyes) and cigarette smoke

Answer: Goodpasture

Flashcard 27: Involvement of lobes of lung in Connective tissue disorders:Lower lobes - RAIDS_____AsbestosisILD (interstitial lung diseases)Drugs: bleomycin, busulfan, amiodarone, methotrexate, nitrofurantoinScleroderma

Answer: Rheumatoid arthritis

Flashcard 28: Treatment of Polymyositis / Dermatomyositis involves _____ followed by long-term methotrexate therapy

Answer: corticosteroids

Flashcard 29: Mixed connective tissue disease has features of _____, scleroderma, and/or polymyositis

Answer: SLE

Flashcard 30: Granulomatosis with polyangiitis often presents with upper respiratory tract symptoms, such as _____ or nasopharyngeal ulceration

Answer: sinusitis

Flashcard 31: Anti-SRP antibodies are associated with _____ and dermatomyositis

Answer: polymyositis

Flashcard 32: Risk factors for rheumatoid arthritis include HLA-_____, smoking, and silica exposure

Answer: DR4

Flashcard 33: The characteristics of SLE may be remembered with the mnemonic "RASH OR PAIN":R: _____A: Arthritis (usually involving > 2 joints)S: Serositis (pleuritis and pericarditis)H: Hematologic disorders (e.g. cytopenias)O: Oral or nasopharyngeal ulcers (usually painless)R: Renal diseaseP: PhotosensitivityA: Antinuclear antibodiesI: Immunologic disorder (anti-dsDNA, anti-Sm, antiphospholipid) N: Neurologic disorder (seizures, psychosis)

Answer: Rash (malar or discoid)

Flashcard 34: _____ disease is characterized by speckled ANA and anti-U1 RNP antibodies

Answer: Mixed connective tissue

Flashcard 35: What antibodies are antiphospholipid antibodies? _____, lupus anticoagulant, and anti-2 glycoprotein

Answer: Anti-cardiolipin

Flashcard 36: Serum sickness presents with fever, urticaria, arthralgia, proteinuria, and lymphadenopathy _____ - 2 weeks after antigen exposure

Answer: 1

Flashcard 37: Behcet syndrome can be precipitated by _____ or parvovirus.

Answer: HSV

Flashcard 38: Granulomatosis with polyangiitis most commonly affects _____ and these patients commonly have a saddle nose deformity

Answer: middle aged men

Flashcard 39: Most common joint involved in _____ is knee

Answer: pseudogout

Flashcard 40: _____-ANCA is triggered by certain infections as proteinase-3 shares similarities with many microbial peptides.

Answer: Anti-proteinase-3/PR3/c

Flashcard 41: _____ syndrome is rheumatoid arthritis with neutropenia and splenomegaly

Answer: Felty

Flashcard 42: Anti-Ro/anti-La in SLE indicates a _____ prognosis, due to decreased risk of nephritis and vasculitis.

Answer: good

Flashcard 43: Autoantibodies seen in dermatomyositis include Anti _____, Anti-NCP2, anti MDA5, and anti- Tlf1.

Answer: Mi2

Flashcard 44: _____ is characterized by sudden onset pain and stiffness in the proximal muscles (i.e. shoulders and hips), without muscular weakness

Answer: Polymyalgia rheumatica

Flashcard 45: Sjogren syndrome can be primary (_____ syndrome) or associated with another autoimmune disorder, especially rheumatoid arthritis

Answer: sicca

Flashcard 46: Reactive arthritis is characterized by a triad of _____, urethritis, and arthritis, with patients often also having diarrhea*patients can also develop?

Answer: conjunctivitis

Flashcard 47: _____ arteritis is associated with polymyalgia rheumatica, which is characterized by aching/stiffness of the shoulders and hips

Answer: Giant cell (temporal)

Flashcard 48: Antiphospholipid syndrome is diagnosed based on clinical criteria including history of _____ or spontaneous abortion along with antiphospholipid antibodies

Answer: thrombosis

Flashcard 49: _____ syndrome is a combination of rheumatoid arthritis and pneumoconiosis with intrapulmonary nodules

Answer: Caplan

Flashcard 50: One complication of long standing rheumatoid arthritis is _____ of the cervical spine

Answer: subluxation

Flashcard 51: What type of Acquired angioedema is often due to an autoantibody that binds C1-INH?_____

Answer: Type II

Flashcard 52: _____ raynaud phenomenon symmetrically affects the digits

Answer: Primary

Flashcard 53: _____symmetric sacroiliitis is a feature of psoriatic arthritis

Answer: A

Flashcard 54: _____ is also known as aortic arch syndrome

Answer: Takayasu's arteritis

Flashcard 55: Muscle tenderness is a _____common feature of dermatomyositis

Answer: un

Flashcard 56: _____ involvement is the most common presentation in men with ankylosing spondylitis.

Answer: Sacroiliac

Flashcard 57: Anti-_____ antibodies are associated with dermatomyositis featuring interstitial lung disease, non-erosive arthritis, and "mechanic's hands"

Answer: Jo1

Flashcard 58: Patients with high titers of antibodies to SS-_____ in Sjogren's syndrome are more likely to have early disease onset; longer disease duration; and extraglandular manifestations

Answer: A

Flashcard 59: Anti-_____ antibodies are associated with dermatomyositis featuring paraneoplastic syndrome

Answer: P155/P140

Flashcard 60: The presence of dysphagia in dermatomyositis points to a _____ prognosis

Answer: poorer

Flashcard 61: Pseudochylothorax is usually caused by conditions such as _____ and tuberculosis

Answer: rheumatoid arthritis

Flashcard 62: According to ACR-EULAR, joint involvement of 4-10 small joints is given a score of _____

Answer: 3

Flashcard 63: _____ criteria is used for the diagnosis of Ankylosing spondylitis

Answer: ASAS

Flashcard 64: Glomerulonephritis is a _____ prognostic indicator in cryoglobulinemic vasculitis

Answer: poor (Poor/Good)

Flashcard 65: Deficiency of IgG4 causes repeated infections with _____ organisms

Answer: parasitic

Flashcard 66: The most common valvular manifestation of rheumatoid arthritis is _____.

Answer: mirtal regurgitation

Flashcard 67: Catastrophic antiphospholipid antibody syndrome (CAPS) is a rapidly progressive thromboembolic disorder simultaneously involving _____ or more organ systems or tissues.

Answer: three

Flashcard 68: Visible dilated capillary loops in proximal nail fold is seen on nail fold capillaroscopy in _____

Answer: dermatomyositis

Flashcard 69: Which vasculitis is commonly associated with development of aortic aneurysms?_____

Answer: Giant cell arteritis

Flashcard 70: Giant capillaries, many hemorrhages and reducing capillary density is seen on nail fold capillaroscopy in _____ pattern

Answer: scleroderma

Flashcard 71: According to ACR-EULAR, joint involvement of 1-3 small joints is given a score of _____

Answer: 2

Flashcard 72: What is the most common cause of secondary increase in SAA protein?_____

Answer: Rheumatoid arthritis

Flashcard 73: According to ACR-EULAR, low positive RF and anti-CCP is given a score of _____

Answer: 2

Flashcard 74: Methotrexate with _____ is used for management of rheumatoid arthritis with joint destruction and disability.

Answer: anti-TNF

Flashcard 75: Telangiectasias and calcinosis are _____ manifestations of systemic sclerosis

Answer: late (early/late)

Flashcard 76: According to ACR-EULAR, abnormal CRP and ESR is given a score of _____

Answer: 1

Flashcard 77: A pleural effusion in case of rheumatoid arthritis will have _____ glucose levels

Answer: low

Flashcard 78: Majority of the patients describe _____ as the first symptom of systemic sclerosis

Answer: Raynaud's Phenomenon

Flashcard 79: _____ aneurysms are commonly associated with Giant Cell arteritis.

Answer: Aortic

Flashcard 80: A pleural effusion in case of rheumatoid arthritis will have _____ protein levels

Answer: high

Flashcard 81: What is the commonest extra-articular manifestation of ankylosing spondylitis?_____

Answer: anterior uveitis

Flashcard 82: _____ raynaud phenomenon progressively worsens in extent and severity over time

Answer: Secondary

Flashcard 83: According to ACR-EULAR, high positive RF and anti-CCP is given a score of _____

Answer: 3

Flashcard 84: According to ACR-EULAR, symptoms for >6 weeks is given a score of _____

Answer: 1

Flashcard 85: According to ACR-EULAR, joint involvement of >10 small joints is given a score of _____

Answer: 5

Flashcard 86: _____ criteria is used for the diagnosis of SLE

Answer: SLICC

Flashcard 87: According to ACR-EULAR, joint involvement of 2-10 large joints is given a score of _____

Answer: 1

Flashcard 88: Anti-_____ antibodies are associated with dermatomyositis featuring gottron papules and heliotrope rash

Answer: Mi2

Flashcard 89: Raynaud's phenomenon is _____ severe in limited cutaneous systemic sclerosis

Answer: more

Flashcard 90: Which multisystemic granulomatous disease will present with polyclonal hyperglobulinemia?_____

Answer: Sarcoidosis

Flashcard 91: Primary biliary cholangitis is most commonly associated with _____ syndrome*also associated with?

Answer: Sjogren

Flashcard 92: Which interleukin is elevated in Castleman's disease?_____

Answer: IL-6

Flashcard 93: Which antibodies are characteristically seen in CNS SLE associated psychosis or depression?_____

Answer: Anti-Ribosomal P

Flashcard 94: A pleural effusion in case of rheumatoid arthritis will have _____ WBC counts

Answer: low

Flashcard 95: What is the next step in mx of a patient of rheumatoid arthritis not responding to oral methotrexate alone (increased severity)?_____

Answer: Add sulfasalazine and HCQ

Flashcard 96: Which inflammatory myopathy is associated with asymmetric muscle involvement?_____

Answer: Inclusion body myositis

Flashcard 97: The most common pulmonary manifestation of rheumatoid arthritis is _____.

Answer: pleuritis

Flashcard 98: Prolonged morning stiffness of joint is found in _____ arthritis

Answer: Rheumatoid

Flashcard 99: The first joints to be involved in rheumatoid arthritis is the _____

Answer: small joints

Flashcard 100: Saturnine gout affects the _____ more than the first metatarsophalangeal joint and tophi rarely develop.

Answer: knee

Flashcard 101: _____ involvement is the most common presentation in women with ankylosing spondylitis.

Answer: Spine

Flashcard 102: _____ criteria is used for the diagnosis of Rheumatoid arthritis

Answer: EULAR

Flashcard 103: _____ is commonly associated with anti-_____ antibodies.

Answer: Drug-induced lupus; histone

Flashcard 104: In _____ arthritis, joint involvement tends to follow 'ray' and 'row' patterns.

Answer: psoriatic

Flashcard 105: _____ presents with features similar to that of Ankylosing spondylitis but without Sacroiliitis.

Answer: Axial spondyloarthritis

Flashcard 106: _____ levels are elevated in sarcoidosis

Answer: ACE

Flashcard 107: Anti-_____ positivity in Systemic sclerosis is useful in predicting those at high risk for interstitial lung disease.

Answer: Scl-70

Flashcard 108: The most common interstitial lung disease associated with Rheumatoid arthritis is _____ interstitial pneumonia

Answer: usual