Contact Dermatitis: Irritant — Flashcards

Flashcard 1: _____ is the only recommended systemic therapy for chronic hand eczema.

Answer: Alitretinoin

Flashcard 2: _____ is the most frequent contact allergen for contact dermatitis

Answer: Nickel

Flashcard 3: _____ dermatitis presents with an intensely pruritic, oozing rash with vesicles and edema due to a type I HSR

Answer: Atopic (eczematous)

Flashcard 4: _____ are the commonest exogenous cause of hand eczema and pompholyx

Answer: Contact irritants/allergens

Flashcard 5: What are the common clinical manifestations and treatment for Chlamydia trachomatis infection?

Answer: Clinical features: Reactive arthritis, conjunctivitis, urethritis, PID. Treatment: Azithromycin or doxycycline.

Extra: Chlamydia trachomatis is an obligate intracellular bacterium. It is the most common bacterial STI. Serovars D-K cause urogenital infections.

Flashcard 6: What are the key characteristics and clinical associations of Campylobacter jejuni?

Answer: Comma-shaped, oxidase (+), grows at 42°C. Causes inflammatory diarrhea (dysentery). Associated with Guillain-Barré syndrome and Reactive arthritis.

Extra: - Morphology: Curved/Comma-shaped rods with polar flagella. - Growth: Thermophilic (grows at 42°C) on Skirrow agar. - Transmission: Poultry, puppies, unpasteurized milk. - Complications: Guillain-Barré syndrome (molecular mimicry with gangliosides) and Reactive arthritis (Reiter syndrome).

Flashcard 7: Name some important clinical conditions caused by _____?

Answer: Pseudomonas aeruginosa

Extra: Characteristics: Gram-negative bacilli, aerobic, oxidase positive. Virulence: Exotoxin A (inhibits EF-2). Treatment: Aminoglycoside + antipseudomonal penicillin (e.g., Piperacillin/Tazobactam).

Flashcard 8: What are the key microbiological characteristics and clinical manifestations of Neisseria gonorrhoeae?

Answer: Gram-negative diplococci; causes gonorrhea, PID, and septic arthritis.

Extra: - Morphology: Gram-negative diplococci. - Key Clinical Features: Gonorrhea, Septic arthritis, Neonatal conjunctivitis, PID, Fitz-Hugh-Curtis syndrome. - Treatment: Ceftriaxone + (Azithromycin or Doxycycline for potential Chlamydia coinfection). - Note: Unlike N. meningitidis, N. gonorrhoeae has NO polysaccharide capsule.

Flashcard 9: Peyronie's disease

Answer: fibrotic tissue formation in penis shaft

Extra: non-painful, bent penis

Flashcard 10: Krukenberg tumor

Answer: GI malignancy mets to ovaries (adenocarcinoma)

Extra: Characterized by mucin-secreting signet-ring cells; usually bilateral metastatic spread from a gastric primary.