Hemoglobin and Myoglobin — Flashcards

Flashcard 1: Sickle cell anemia occurs due to a point mutation that substitutes _____ (hydrophilic) with valine (hydrophobic)

Answer: glutamic acid

Flashcard 2: What are the stabilizing bonds in quaternary protein structure?

Answer: Hydrophobic interactions > Hydrogen bonds > Ionic bonds

Flashcard 3: What is the stabilizing bond in tertiary protein structure?_____

Answer: Hydrophobic bond>Hydrogen bond>Ionic bond

Flashcard 4: When _____ acts on a molecule of immunoglobulin, the end products are _____ fragment and many smaller fragments

Answer: pepsin; 1 F(ab')2

Flashcard 5: _____, the 21st amino acid, is coded by the _____ codon by co-translational modification.

Answer: Selenocysteine; UGA

Flashcard 6: Curve A indicates which compound? _____

Answer: Myoglobin

Flashcard 7: The given image represents a _____ which is a secondary structure of proteins.

Answer: beta-sheet

Flashcard 8: egg white forms _____% weight of egg

Answer: 60

Extra: 

Flashcard 9: Serum _____ is the most sensitive indicator for protein estimation (nutritional status).

Answer: pre-albumin

Extra: • **Pre-albumin (Transthyretin):** Most sensitive indicator (Half-life ≈ 2 days). • **Albumin:** Indicator of chronic nutritional status (Half-life ≈ 20 days). • **Retinol-binding protein:** Even shorter half-life (~12 hours) but less commonly tested. Note: Albumin is a negative acute-phase reactant, meaning its levels drop during inflammation regardless of nutritional status.

Flashcard 10: Collagen Synthesis: Once in the extracellular space, cleavage of disulfide-rich terminal regions of procollagen by _____ forms the insoluble tropocollagen

Answer: procollagen peptidase