Gastroenterology & Hepatology Practice Questions

Question 1

A 42-year-old woman presents with fatigue, muscle aches, and widespread pain. She has multiple tender points but normal inflammatory markers. Sleep is poor. What is the most appropriate initial treatment?

Accepted Answer

Pregabalin

Answer

NSAIDs

Answer

Prednisolone

Answer

Methotrexate

Answer

Physiotherapy alone

Question 2

A 57-year-old diabetic man presents with a non-healing foot ulcer for 3 months. Ankle-brachial pressure index is 0.3. What does this indicate?

Accepted Answer

Severe arterial disease

Answer

Normal arterial supply

Answer

Mild arterial disease

Answer

Moderate arterial disease

Answer

Venous disease

Question 3

A 49-year-old man presents with progressive weakness in his arms and legs over 24 months. He has bulbar symptoms including dysphagia and dysarthria. EMG shows widespread denervation. What is the most important prognostic factor?

Accepted Answer

Bulbar involvement

Answer

Age at onset

Answer

Rate of progression

Answer

Site of onset

Answer

Family history

Question 4

A 38-year-old woman presents with recurrent episodes of severe abdominal pain and psychiatric symptoms. Her urine turns dark during attacks. Family history reveals similar episodes. What is the inheritance pattern?

Accepted Answer

Autosomal dominant

Answer

Autosomal recessive

Answer

X-linked recessive

Answer

X-linked dominant

Answer

Mitochondrial

Question 5

A 47-year-old man presents with acute severe abdominal pain and vomiting. He has a family history of similar episodes. Serum amylase is normal but urinary porphobilinogen is elevated. What triggers should be avoided?

Accepted Answer

All of the above

Answer

Fasting

Answer

Alcohol

Answer

Barbiturates

Answer

Stress

Question 6

A 51-year-old woman presents with progressive dysphagia and weight loss. She has a history of Barrett's esophagus on surveillance. Upper endoscopy shows a stricturing lesion. What is the most appropriate next step?

Accepted Answer

Multiple biopsies of the lesion

Answer

Barium swallow

Answer

CT chest and abdomen

Answer

Endoscopic ultrasound

Answer

PET scan

Question 7

A 43-year-old woman presents with episodes of flushing, diarrhea, and bronchospasm. CT shows liver metastases and a small bowel mass. 24-hour urine 5-HIAA is markedly elevated. What is the primary tumor location?

Accepted Answer

Small bowel

Answer

Appendix

Answer

Pancreas

Answer

Lung

Answer

Ovary

Question 8

A 54-year-old man presents with progressive dysphagia to solids over 3 months. He has a 40-year history of heartburn. Upper endoscopy shows a stricturing lesion at the GE junction. What is the most likely diagnosis?

Accepted Answer

Esophageal adenocarcinoma

Answer

Benign peptic stricture

Answer

Achalasia

Answer

Eosinophilic esophagitis

Answer

Esophageal web

Question 9

A 52-year-old man presents with progressive jaundice and weight loss. MRCP shows stricturing of the common bile duct with upstream dilatation. CA 19-9 is markedly elevated. What is the most likely diagnosis?

Accepted Answer

Cholangiocarcinoma

Answer

Choledocholithiasis

Answer

Pancreatic adenocarcinoma

Answer

Primary sclerosing cholangitis

Answer

Chronic pancreatitis

Question 10

A 41-year-old man presents with recurrent episodes of severe flushing and diarrhea. He develops bronchospasm during episodes. 5-HIAA is elevated. What is the primary tumor site likely to be?

Accepted Answer

Small bowel

Answer

Lung

Answer

Pancreas

Answer

Stomach

Answer

Colon

Gastroenterology & Hepatology

Study Resources

Lessons

Questions

Flashcards

Lessons

Acute pancreatitis

Cirrhosis and complications

Dyspepsia and GORD

Inflammatory bowel disease

Irritable bowel syndrome

Upper GI bleeding

Practice Questions

Flashcards

About Gastroenterology & Hepatology for UKMLA

Lessons in Gastroenterology & Hepatology

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