Pharmacokinetics and Pharmacodynamics Practice Questions

Question 1

A 70 kg man was given a drug with a dose of 100 mg/kg body weight, twice daily. The half-life (t1/2) is 10 hours, the plasma concentration is 1.9 mg/mL, and the clearance is unknown. What is the clearance of this drug?

Accepted Answer

0.22 L/hr

Answer

20 liter/hr

Answer

K is 0.0693

Answer

0.02 L/hr

Question 2

In which phase of clinical trials is drug dosing typically determined?

Accepted Answer

Phase 1

Answer

Phase 2

Answer

Phase 3

Answer

Phase 4

Answer

Phase 0

Question 3

A drug with high plasma protein binding property has which of the following properties?

Accepted Answer

Lower volume of distribution

Answer

Reduced renal clearance

Answer

Less drug interaction

Answer

Less tubular secretion

Question 4

Lidocaine is used in a loading dose for the treatment of arrhythmias. The loading dose of this drug depends upon which of the following factors?

Accepted Answer

Volume of distribution

Answer

Clearance

Answer

Half-life

Answer

Bioavailability

Answer

Elimination rate constant

Question 5

Match the following drugs in Column A with their contraindications in Column B.

Accepted Answer

A-4, B-1, C-3, D-2

Answer

A-1, B-3, C-2, D-4

Answer

A-3, B-2, C-4, D-1

Answer

A-2, B-4, C-1, D-3

Question 6

What do A and B represent in the curve shown below?

Accepted Answer

A= Median effective dose, B= Median lethal dose

Answer

A= Therapeutic index, B= Median efficacy

Answer

A= Median lethal dose, B= Median effective dose

Answer

A= Median efficacy, B= Therapeutic index

Question 7

Drug X has an affinity for albumin, while drug Y has 150 times greater affinity. Which of the following statements is MOST accurate?

Accepted Answer

The free concentration of drug X in blood is higher, facilitating tissue distribution.

Answer

Drug X will be more available in tissues

Answer

Drug Y will be less available in tissues

Answer

Toxicity of drug Y may be influenced by multiple factors, not just its binding.

Question 8

Continued suppression of bacterial growth after antibiotic levels have fallen below the Minimum Inhibitory Concentration (MIC) is known as?

Accepted Answer

Post antibiotic effect

Answer

Time dependent killing

Answer

Sequential blockade

Answer

Concentration dependent killing

Question 9

Which of the following is excreted in saliva?

Accepted Answer

Lithium

Answer

Chloramphenicol

Answer

Ampicillin

Answer

Tetracycline

Question 10

Low apparent volume of distribution of drug indicates that:

Accepted Answer

Drug is not extensively distributed to tissue

Answer

Drug has low bioavailability

Answer

Drug has low efficacy

Answer

Drug has low half life

Pharmacokinetics and Pharmacodynamics

Study Resources

Lessons

Questions

Flashcards

Lessons

Absorption and Bioavailability

Drug Distribution and Protein Binding

Biotransformation and Metabolism Pathways

Renal and Non-renal Excretion

Compartment Models

Dose-Response Relationships

Drug Efficacy and Potency

Drug Tolerance and Tachyphylaxis

Population Pharmacokinetics

Pharmacokinetic Variability

Practice Questions

Flashcards

About Pharmacokinetics and Pharmacodynamics for NEET-PG

Lessons in Pharmacokinetics and Pharmacodynamics

Master Pharmacokinetics and Pharmacodynamics