Molecular Pathology Practice Questions

Question 1

Techniques used for protein expression proteomics study include:

Accepted Answer

All of the options

Answer

PolyAcrylamide Gel Electrophoresis (PAGE)

Answer

Gene Expression Analysis (indirectly related to proteomics)

Answer

Mass Spectrometry

Question 2

Which of the following is a primarily RNA based technique?

Accepted Answer

Northern blotting

Answer

Western blotting

Answer

Southern blotting

Answer

Sanger's technique

Question 3

Which of the following are correct with regard to lung cancer?

1. Surgical resection has a limited role in curative treatment of lung cancer.
2. Pattern of disease and prognosis of oat cell carcinoma are different to other varieties in the lungs.
3. Small cell lung cancer is a type of Neuroendocrine Tumour (NET).
4. Squamous cancer appears as a cavitating tumour in the lungs.

Accepted Answer

2, 3 and 4

Answer

1, 3 and 4

Answer

1, 2 and 3

Answer

1, 2 and 4

Question 4

Which of the following is the most fundamental criterion that must be met by a disease before it is to be considered suitable for a screening programme?

1. The natural history of the disease should be adequately understood.
2. No effective treatment should exist for the disease.
3. The disease should not have a recognizable latent or asymptomatic stage.
4. There should be a test that can detect the disease prior to onset of signs and symptoms.

Accepted Answer

1. The natural history of the disease should be adequately understood.

Answer

4. There should be a test that can detect the disease prior to onset of signs and symptoms.

Answer

3. The disease should not have a recognizable latent or asymptomatic stage.

Answer

2. No effective treatment should exist for the disease.

Question 5

A patient has a cerebellar mass, renal tumor, and a family history of similar conditions. Which of the following mutations is most likely present in the family?

Accepted Answer

VHL

Answer

Neurofibromatosis (NF1)

Answer

Tuberous Sclerosis Complex (TSC)

Answer

Li-Fraumeni syndrome

Question 6

Knudson two-hit hypothesis is classically exemplified by

Accepted Answer

Retinoblastoma

Answer

Crohn disease

Answer

Ulcerative colitis

Answer

Melanoma

Question 7

Which of the following are criteria for cancer screening?
I. Screening test should be sensitive and specific
II. Screening test should be acceptable to the screened population
III. The disease should be an uncommon one for screening to be effective
IV. Disease should be recognisable at an early stage
Select the correct answer using the code given below :

Accepted Answer

I, II and IV

Answer

II, III and IV

Answer

I, III and IV

Answer

I, II and III

Question 8

Which of the following statements are correct with regard to Familial Adenomatous Polyposis ?

1. It is associated with mutation of APC gene located on the long arm of chromosome 5.
2. It is inherited as an autosomal recessive condition.
3. It is associated with 100% lifetime risk for development of Colorectal carcinoma.
4. Congenital hypertrophy of retinal pigment epithelium is present in half of the cases of familial adenomatous polyposis.

Select the correct answer using the code given below :

Accepted Answer

1, 3 and 4

Answer

1, 2 and 3

Answer

2, 3 and 4

Answer

1, 2 and 4

Question 9

BRCA1 gene is located on which chromosome?

Accepted Answer

17q21

Answer

13q12

Answer

12q13

Answer

21q17

Question 10

Agarose gel electrophoresis from DNA of a population of cells as seen under ultraviolet light is shown below. What is the correct explanation for the finding seen in the band labeled as "C"?

Accepted Answer

Apoptotic cells

Answer

Predominantly necrotic cells

Answer

Mixed population of normal and apoptotic cells

Answer

A population of viable cells

Molecular Pathology

Study Resources

Lessons

Questions

Flashcards

Lessons

Principles of Molecular Pathology

DNA and RNA Analysis Techniques

Cytogenetics

Polymerase Chain Reaction Applications

Next-Generation Sequencing

Molecular Diagnosis of Infectious Diseases

Molecular Oncology

Pharmacogenomics

Genetic Counseling and Risk Assessment

Molecular Diagnostics Quality Control

Practice Questions

Flashcards

About Molecular Pathology for NEET-PG

Lessons in Molecular Pathology

Master Molecular Pathology