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A 48-year-old woman with alpha-1-antitrypsin deficiency undergoes a lung transplant. She tolerates the surgery well, but 3 years later develops inflammation and fibrosis in her terminal bronchioles. Which of the following best describes the pathophysiology of this patient's deterioration?
In which of the following pathological states would the oxygen content of the trachea resemble the oxygen content in the affected alveoli?
An 82-year-old woman is admitted to the hospital because of wet gangrene on her right leg. Two days after admission, she becomes increasingly confused and tachypneic. She is intubated and ventilatory support is initiated. Her temperature is 39.6°C (102.5°F), pulse is 127/min, and blood pressure is 83/47 mm Hg. The ventilator is set at a FiO2 of 100% and a respiratory rate of 20/min. An arterial blood gas checked 30 minutes after intubation shows a PCO2 of 41 mm Hg and a PO2 of 55 mm Hg. Despite appropriate care, the patient dies from respiratory failure. Further evaluation of this patient is most likely to show which of the following findings?
Atelectasis
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Pulmonary edema
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Acute respiratory distress syndrome
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Obstructive lung diseases (emphysema, bronchitis)
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Asthma pathology
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Bronchiectasis
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Restrictive lung diseases
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Interstitial lung diseases
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Pulmonary vascular disorders
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Pulmonary infections
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Lung tumors (primary and metastatic)
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Pleural diseases
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Congenital lung anomalies
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