Hereditary Cancer Syndromes — MCQs

A patient presents with headaches, palpitations, hypertension, and urine VMA positivity. The biopsy findings are shown in the image. Which of the following statements is correct?

Which of the following is not a premalignant condition?

BRCA1 gene lies on chromosome

A patient has a cerebellar mass, renal tumor, and a family history of similar conditions. Which of the following mutations is most likely present in the family?

Which of the following genes is least likely to be involved in the development of carcinoma of the colon?

Familial retinoblastoma is characterized by which of the following statements?

Which of the following cancers is least associated with BRCA2 mutations?

Which of the following statements are true about familial adenomatous polyposis? 1. It is autosomal recessive 2. If not treated, 100% of the cases progress to adenocarcinoma colon. 3. It is associated with a gene mutation in KRAS 4. It is associated with congenital hypertrophy of the retinal pigment epithelium.

Which of the following statements about Von-Hippel Lindau syndrome is true:

HNPCC has defect in which