Oncoplastic Breast Surgery — MCQs
Which of the following stages of Breast Cancer corresponds to the following features: a breast mass of 6 x 3 cm, ipsilateral supraclavicular lymph node involvement, and distant metastasis that cannot be assessed?
Complications of sling procedures (TVT) for USI are all except:
In which of the following types of breast carcinoma would you consider a biopsy of the opposite breast?
In which of the following situations is breast conservation surgery not indicated?
Which of the following conditions is not typically treated with a simple mastectomy?
Which flap is commonly used in breast reconstruction?
Most common complication of mastectomy is:
A 55-year-old female patient presented with a $4 \times 3 \mathrm{~cm}$ lump in the right upper outer quadrant, with no axillary lymph node involvement. Mammography revealed BIRADS 4b staging. She underwent breast conservation surgery, and the final HPE report showed high nuclear-grade DCIS with necrosis and 10 mm margin clearance. What is the further management?
A patient presents to the OPD with a right-sided ulcerated breast lesion. Radiological imaging shows liver metastasis, as seen in the provided ultrasound image. What is the most appropriate management?
Which of the following is a contraindication to breast conservation surgery?
Oncoplastic Breast Surgery Indian Medical PG Practice Questions and MCQs
Question 1: Which of the following stages of Breast Cancer corresponds to the following features: a breast mass of 6 x 3 cm, ipsilateral supraclavicular lymph node involvement, and distant metastasis that cannot be assessed?
- A. T4 N3 MX
- B. T4 N1 M1
- C. T4 N0 M0
- D. T3 N3c MX (Correct Answer)
Explanation: ***T3 N3c MX*** - A **breast mass of 6 x 3 cm** indicates a T3 tumor (tumor size > 5 cm). - **Ipsilateral supraclavicular lymph node involvement** is classified as N3c disease. **Distant metastasis that cannot be assessed** is denoted by MX. *T4 N3 MX* - A **T4 classification** is reserved for tumors with direct extension to the chest wall or skin, or inflammatory breast cancer, which is not mentioned here. - While N3c and MX are correct for the nodal and metastatic status, the T stage is inaccurate based on the provided tumor size. *T4 N1 M1* - A **T4 classification** is incorrect as the mass size alone (6 x 3 cm) does not meet T4 criteria. - **N1** denotes involvement of 1-3 axillary lymph nodes, which is less extensive than supraclavicular involvement (N3c). **M1** indicates confirmed distant metastasis, but the question states it "cannot be assessed" (MX). *T4 N0 M0* - **T4** is incorrect, as this stage is for direct chest wall/skin involvement or inflammatory breast cancer. - **N0** signifies no regional lymph node metastasis, contradicting the presence of supraclavicular lymph node involvement. **M0** indicates no distant metastasis, whereas the question specifies it cannot be assessed (MX).
Question 2: Complications of sling procedures (TVT) for USI are all except:
- A. Obturator nerve injury is about 10% (Correct Answer)
- B. Overactive bladder in about 7% cases
- C. Injury to bladder and wound haematoma
- D. Sling erosion particularly with polytetrafluoroethylene (Goretex)
Explanation: ***Obturator nerve injury is about 10%*** ✓ **CORRECT ANSWER (NOT a complication of TVT)** - **Obturator nerve injury** is exceedingly rare during **TVT (Tension-free Vaginal Tape)** procedures, which use a retropubic approach through the space of Retzius. - This complication is primarily associated with **TOT (Trans-Obturator Tape)** procedures where the tape passes near the obturator foramen, not with standard retropubic TVT. - The incidence of obturator nerve injury in TVT is essentially negligible (<0.1%), nowhere near 10%. *Overactive bladder in about 7% cases* - **De novo overactive bladder (OAB)** symptoms or worsening of pre-existing OAB can occur in 3-15% of patients after TVT procedures, with 7% being a commonly cited figure. - This occurs due to changes in bladder neck support, urethral kinking, or irritation from the sling material. *Injury to bladder and wound haematoma* - **Bladder injury/perforation** occurs in 2-5% of TVT cases due to the retropubic passage of needles close to the bladder, which is why intraoperative cystoscopy is routinely performed. - **Wound hematoma** can occur at the vaginal or suprapubic incision sites as a common surgical complication from tissue dissection and bleeding. *Sling erosion particularly with polytetrafluoroethylene (Goretex)* - **Sling erosion** into the vagina or urethra is a documented complication of synthetic slings, with rates of 0.5-3% for modern materials. - **Polytetrafluoroethylene (Goretex)**, an older first-generation mesh material, was associated with significantly higher rates of erosion (up to 10%) and infection compared to modern monofilament polypropylene meshes, which is why it has been largely discontinued for sling procedures.
Question 3: In which of the following types of breast carcinoma would you consider a biopsy of the opposite breast?
- A. Lobular carcinoma (Correct Answer)
- B. Comedo carcinoma
- C. Medullary carcinoma
- D. Adenocarcinoma-poorly differentiated
Explanation: ***Lobular carcinoma*** - **Invasive lobular carcinoma (ILC)** is known for its **multicentricity** (multiple foci within the same breast) and a higher incidence of **bilateral involvement** compared to other breast cancer types. - Due to its infiltrating growth pattern without significant desmoplasia, ILC can be **clinically subtle** and difficult to detect by imaging, thus biopsy of the contralateral breast may be considered if there are any suspicious findings. *Comedo carcinoma* - This is a subtype of **ductal carcinoma in situ (DCIS)** characterized by central necrosis, calcifications, and high-grade nuclei confined to the ducts. - While DCIS can recur or progress, its primary concern is typically within the affected breast, and it does not inherently carry a significantly increased risk of contralateral involvement requiring routine biopsy. *Medullary carcinoma* - **Medullary carcinoma** is a rare subtype of invasive ductal carcinoma known for its distinct histological features, including a pushing border, prominent lymphocytic infiltrate, and high-grade nuclei. - It generally has a **better prognosis** than other invasive ductal carcinomas and does not have a characteristically high incidence of bilateral involvement that would routinely warrant a contralateral breast biopsy. *Adenocarcinoma-poorly differentiated* - This term describes an **invasive ductal carcinoma** with a high histologic grade, indicating aggressive features and poor differentiation. - While any invasive breast cancer carries some risk of bilateral disease, poorly differentiated adenocarcinoma does not have the uniquely high predisposition for **contralateral synchronous or metachronous disease** that is characteristic of lobular carcinoma.
Question 4: In which of the following situations is breast conservation surgery not indicated?
- A. SLE
- B. Large pendular breast
- C. Diffuse microcalcification
- D. All of the options (Correct Answer)
Explanation: ***All of the options*** - All listed scenarios—**large pendular breast**, **SLE**, and **diffuse microcalcification**—represent situations where breast conservation surgery is generally contraindicated or challenging. - Their presence often necessitates alternative treatment approaches, such as mastectomy, to achieve optimal oncologic and cosmetic outcomes. *Large pendular breast* - While not an absolute contraindication, a **very large or pendulous breast** can make it difficult to achieve a satisfactory cosmetic outcome after breast conservation surgery. - The disproportionate breast size post-lumpectomy may lead to significant **asymmetry**, requiring further reconstructive procedures. *SLE* - Patients with **Systemic Lupus Erythematosus (SLE)** are at an increased risk of complications from radiation therapy, a mandatory component of breast conservation surgery. - They tend to experience more severe and prolonged **acute and chronic skin reactions** to radiation, which can significantly impair healing and quality of life. *Diffuse microcalcification* - **Diffuse microcalcification** within the breast can indicate widespread in situ carcinoma (e.g., DCIS) or an invasive carcinoma with extensive intraductal component. - In such cases, achieving **clear surgical margins** with breast conservation surgery can be challenging and often leads to multiple re-excisions or an increased risk of local recurrence.
Question 5: Which of the following conditions is not typically treated with a simple mastectomy?
- A. Paget's disease
- B. Fibroadenoma (Correct Answer)
- C. Cystosarcoma phyllodes
- D. None of the options
Explanation: ***Fibroadenoma*** - A **fibroadenoma** is a **benign tumor** of the breast that typically does not require a mastectomy for treatment. - Treatment usually involves **observation**, **excision**, or **cryoablation**, depending on size, symptoms, and patient preference. *Paget's disease* - **Paget's disease of the breast** is a rare form of breast cancer that affects the nipple and areola, and is typically associated with an underlying **ductal carcinoma in situ** (DCIS) or **invasive breast cancer**. - Due to the presence of malignancy and its superficial spread, **mastectomy** (simple or modified radical) is often the recommended treatment, especially for extensive disease. *Cystosarcoma phyllodes* - Formerly known as **phyllodes tumor**, this is a rare **stromal tumor** of the breast that can be benign, borderline, or malignant. - Due to its potential for local recurrence and, in malignant cases, metastasis, **wide local excision with clear margins** is crucial, and a **simple mastectomy** may be necessary for large or recurrent tumors to achieve adequate margin control. *None of the options* - This option is incorrect because fibroadenoma is a condition not typically treated with a simple mastectomy, unlike Paget's disease and cystosarcoma phyllodes.
Question 6: Which flap is commonly used in breast reconstruction?
- A. DIEP based on deep inferior epigastric perforator vessels (Correct Answer)
- B. Gluteal flap based on superior gluteal artery
- C. Latissimus dorsi flap based on thoracodorsal artery
- D. TRAM based on transverse rectus abdominis muscle
Explanation: ***DIEP based on deep inferior epigastric perforator vessels*** - The **DIEP flap** is currently the **most preferred autologous flap** for breast reconstruction and is increasingly commonly used in modern practice. - It uses tissue from the lower abdomen, providing excellent volume and a natural-feeling breast mound, while being nourished by **deep inferior epigastric perforator vessels**. - Key advantage: **Muscle-sparing technique** that preserves the rectus abdominis muscle, minimizing abdominal wall morbidity compared to older techniques like TRAM. - Considered the **gold standard** for abdominal-based breast reconstruction. *Gluteal flap based on superior gluteal artery* - While gluteal flaps (like the **SGAP** based on the **superior gluteal artery**) are used for breast reconstruction, they are typically considered a secondary option when abdominal tissue is unavailable or unsuitable. - Harvesting can be more challenging and may result in a less ideal breast shape compared to abdominal flaps. - Less commonly used compared to abdominal-based flaps. *Latissimus dorsi flap based on thoracodorsal artery* - The **latissimus dorsi flap** is a reliable and commonly used option, particularly for smaller breasts or partial reconstruction. - However, it often requires an implant to achieve sufficient volume (not purely autologous reconstruction). - It involves transferring muscle from the back, which can lead to back weakness or contour deformities. - While frequently used, it is not the preferred choice when autologous tissue from the abdomen is available. *TRAM based on transverse rectus abdominis muscle* - The **TRAM flap** was historically a very common choice for breast reconstruction but involves taking a significant portion of the rectus abdominis muscle. - This leads to higher rates of abdominal wall weakness, hernias, or bulges compared to muscle-sparing techniques. - It is currently **less commonly used** than the DIEP flap due to its higher donor site morbidity and has been largely superseded by the DIEP technique.
Question 7: Most common complication of mastectomy is:
- A. Seroma (Correct Answer)
- B. Hemorrhage
- C. Infection
- D. Lymphedema
Explanation: ***Seroma*** - **Seroma** formation is the most common complication after mastectomy, involving the accumulation of serous fluid in the surgical dead space. - This complication can lead to discomfort, delayed wound healing, and an increased risk of infection. *Hemorrhage* - While a serious complication, **hemorrhage** is less common than seroma formation. - Significant hemorrhage usually occurs intraoperatively or in the immediate postoperative period and is typically managed promptly. *Lymphedema* - **Lymphedema** is a chronic condition characterized by swelling of the arm due to impaired lymphatic drainage, often developing months to years after surgery. - Although highly significant and debilitating, its incidence is lower than acute complications like seroma. *Infection* - Surgical site **infection** is a potential complication but is generally less frequent than seroma due to careful aseptic techniques and prophylactic antibiotics. - Infections can range from superficial wound infections to more serious cellulitis.
Question 8: A 55-year-old female patient presented with a $4 \times 3 \mathrm{~cm}$ lump in the right upper outer quadrant, with no axillary lymph node involvement. Mammography revealed BIRADS 4b staging. She underwent breast conservation surgery, and the final HPE report showed high nuclear-grade DCIS with necrosis and 10 mm margin clearance. What is the further management?
- A. Follow up 6 monthly for 2 years and then yearly follow up
- B. Trastuzumab therapy
- C. Adjuvant chemotherapy
- D. Adjuvant radiotherapy (Correct Answer)
Explanation: ***Adjuvant radiotherapy*** - For **high-grade DCIS** with necrosis after breast conservation surgery, adjuvant radiotherapy significantly reduces the risk of **local recurrence** (by approximately 50%). - Even with adequate margin clearance (10 mm), radiotherapy is recommended to treat **potential residual microscopic disease** elsewhere in the breast tissue. - This is the **standard of care** for high-grade DCIS post-BCS, particularly when necrosis is present. *Follow up 6 monthly for 2 years and then yearly follow up* - While regular follow-up is essential for all breast cancer patients, it is **not sufficient alone** for high-grade DCIS treated with breast conservation. - **Adjuvant radiotherapy** is necessary to reduce recurrence risk before initiating the follow-up schedule. *Trastuzumab therapy* - **Trastuzumab** is specifically indicated for **HER2-positive invasive breast cancer**. - The patient has **DCIS**, which is **non-invasive (in situ)**, making trastuzumab inappropriate. - There is no role for targeted therapy in DCIS management. *Adjuvant chemotherapy* - **Adjuvant chemotherapy** is generally reserved for **invasive breast cancers**, especially those with high-risk features like lymph node involvement or aggressive tumor biology. - For **DCIS**, even high-grade with necrosis, chemotherapy is **not indicated** as it provides no proven benefit for non-invasive disease.
Question 9: A patient presents to the OPD with a right-sided ulcerated breast lesion. Radiological imaging shows liver metastasis, as seen in the provided ultrasound image. What is the most appropriate management?
- A. Simple mastectomy
- B. Modified Radical Mastectomy (MRM)
- C. Radical mastectomy
- D. Neoadjuvant chemotherapy followed by surgery (Correct Answer)
Explanation: ***Neoadjuvant chemotherapy followed by surgery*** - The presence of **distant metastasis** (liver metastasis) indicates **Stage IV breast cancer**, where **systemic treatment is the primary goal**. - In Stage IV disease, **palliative systemic chemotherapy** is the mainstay of treatment to control distant disease and improve survival. - Surgery in metastatic breast cancer may be considered for **local control of symptomatic disease** (ulceration, bleeding, pain), typically after initiating systemic therapy. - The combination of systemic therapy followed by local surgery for the ulcerated lesion addresses both the metastatic disease and provides local symptom relief. *Simple mastectomy* - While this could provide local control of the ulcerated lesion, it does **not address the distant metastasis**. - In Stage IV disease, **systemic therapy must be prioritized** before considering any local surgical intervention. - Surgery alone without systemic treatment would be inadequate for metastatic disease. *Modified Radical Mastectomy (MRM)* - MRM involves removal of the entire breast tissue, skin, nipple-areolar complex, and level I and II axillary lymph nodes. - While this provides comprehensive local-regional control, it **does not address distant metastasis**. - In Stage IV disease, extensive locoregional surgery without systemic therapy first would be inappropriate, as the primary issue is systemic disease. *Radical mastectomy* - This extensive procedure involves removal of the breast, axillary lymph nodes, and pectoralis muscles. - It is **rarely performed today** due to significant morbidity and no survival benefit over less extensive procedures. - Like other surgical options alone, it fails to address the systemic nature of Stage IV disease.
Question 10: Which of the following is a contraindication to breast conservation surgery?
- A. Presence of multicentric tumors (Correct Answer)
- B. Involvement of axillary lymph nodes
- C. Tumor size greater than 4 cm
- D. Presence of diffuse microcalcifications
Explanation: ***Presence of multicentric tumors*** - **Multicentric tumors** are defined as two or more discrete tumors in different quadrants of the breast, which cannot be removed with a single lumpectomy. - This condition is a contraindication for breast conservation surgery (BCS) because complete removal of all tumor foci while maintaining an acceptable cosmetic outcome is highly unlikely. *Involvement of axillary lymph nodes* - **Axillary lymph node involvement** is an important prognostic factor in breast cancer and influences adjuvant therapy decisions, but it is not a direct contraindication to BCS. - Patients with positive nodes often undergo axillary dissection or sentinel lymph node biopsy, followed by radiation and/or systemic therapy, which can be combined with BCS. *Tumor size greater than 4 cm* - While larger tumor size (e.g., >4-5 cm) can make achieving negative surgical margins and a good cosmetic outcome more challenging with BCS, it is not an absolute contraindication. - **Neoadjuvant chemotherapy** can often downstage larger tumors, making BCS a viable option for many patients. *Presence of diffuse microcalcifications* - **Diffuse microcalcifications** can sometimes indicate extensive ductal carcinoma in situ (**DCIS**) or invasive lobular carcinoma with a widespread component. - However, if the microcalcifications represent a single focus of disease that can be entirely excised with negative margins, BCS may still be an option, especially if guided by stereotactic biopsy and imaging.
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