Post-treatment Breast Imaging — MCQs
What is the investigation of choice for whole body imaging in metastatic breast cancer?
Which of the following features suggests a malignant lesion on mammography?
Gold standard investigation for breast carcinoma screening in a patient with silicone breast implants
On mammogram, all of the following are the features of a malignant tumor except:
Most common complication of mastectomy is:
Best investigation to detect rupture of silicone breast implants is-
Which of the following is the most sensitive investigation for ductal carcinoma in situ (DCIS) of the breast?
A middle aged male patient presents with painless slow growing neck swelling. On examination, lymph nodes are positive. Surgery is done and biopsy is shown in the image below. Which of the following is false regarding the HPE findings?
Which of the following are correct in the treatment of cracked nipple? I. Correct attachment (Latch on) will provide immediate relief from pain and rapid healing. II. If pain, mother should use breast pump and the infant is fed with the expressed milk. III. Antifungal medication (such as miconazole or nystatin) is applied to treat both the mother's nipple and the baby's mouth if there is oral thrush. Select the answer using the code given below:
A patient of road traffic accident presents to the emergency with increasing restlessness and difficulty in breathing. The respiratory rate is 26 breaths/minute; there are distended neck veins; trachea is deviated to the right side with hyper-resonant note and absence of breath sounds on the left side. Which of the following statements are correct? 1. The most probable clinical diagnosis is left tension pneumothorax 2. Immediate chest decompression using wide bore cannula in left 2nd intercostal space is to be done 3. Immediate chest X-ray should be done to confirm the clinical diagnosis 4. Definitive chest tube insertion in left fifth intercostal space should be done
Post-treatment Breast Imaging Indian Medical PG Practice Questions and MCQs
Question 1: What is the investigation of choice for whole body imaging in metastatic breast cancer?
- A. Angiography
- B. Venography
- C. Magnetic Resonance Imaging
- D. CT Scan (Correct Answer)
Explanation: ***CT Scan (Correct answer for NEET 2013)*** - **Contrast-enhanced CT scan** was the standard imaging modality for **whole-body staging** in metastatic breast cancer at the time of this exam (2013). - CT offers **excellent spatial resolution** for detecting metastases in **bone, lung, liver, and lymph nodes**. - It is widely available, relatively quick, and provides comprehensive anatomical information. - **Modern Update:** While CT was the standard in 2013, **PET-CT (FDG-PET/CT) is now considered the gold standard** for whole-body staging in metastatic breast cancer due to its combined metabolic and anatomical imaging capabilities. However, PET-CT was not among the options in this historical question. *Magnetic Resonance Imaging* - **MRI** is highly sensitive for specific sites, particularly for **brain metastases** and **bone metastases (especially spine and bone marrow)**. - **Whole-body MRI** protocols are emerging but require longer acquisition times and specialized equipment. - Not ideal as a single first-line modality for comprehensive whole-body staging compared to CT (or modern PET-CT). *Angiography* - **Angiography** is an invasive vascular imaging procedure used to visualize **arterial blood flow**. - It has **no role in routine metastatic screening or staging** of breast cancer. - Reserved for specific indications like preoperative vascular mapping or interventional procedures. *Venography* - **Venography** specifically visualizes **venous structures** and is used to detect venous thrombosis or venous obstructions. - It is **not applicable** for detecting solid organ metastases, bone lesions, or lymph node involvement in cancer staging.
Question 2: Which of the following features suggests a malignant lesion on mammography?
- A. Macrocalcifications
- B. Microcalcifications (Correct Answer)
- C. Fat content
- D. Round well defined borders
Explanation: ***Microcalcifications*** - **Fine, pleomorphic, branching, or linear calcifications** clustered together are highly suspicious for malignancy, particularly **ductal carcinoma in situ (DCIS)**. - They represent calcium deposits within the ducts or stromal calcifications related to tumor cells. *Macrocalcifications* - These are **larger, coarser calcifications** (typically >0.5 mm) which are almost universally benign. - They are often associated with benign conditions such as **fibroadenomas**, old trauma, or vascular calcifications. *Fat content* - Lesions predominantly composed of fat, such as **lipomas**, **oil cysts**, and **hamartomas**, are typically benign. - The presence of fat within a lesion on mammography generally indicates a **benign process**. *Round well defined borders* - A **smooth, rounded, and well-circumscribed margin** on mammography is a strong indicator of a benign lesion. - Malignant lesions typically have **irregular, spiculated, or ill-defined margins** due to invasive growth.
Question 3: Gold standard investigation for breast carcinoma screening in a patient with silicone breast implants
- A. Mammography
- B. CT scan
- C. USG
- D. MRI (Correct Answer)
Explanation: ***MRI*** - **MRI** is considered the **gold standard** for breast cancer screening in patients with silicone breast implants due to its superior ability to visualize breast tissue through the implant and detect subtle lesions. - It offers **high sensitivity** in detecting both implant rupture and early malignancies, often providing better clarity than mammography in augmented breasts where implants can obscure tissue. *Mammography* - While a standard screening tool, **mammography** can be limited in patients with silicone implants because the implants can **obscure adjacent breast tissue**, making detection of small masses challenging. - Special views (e.g., **Eklund views**) can be used, but sensitivity is still reduced compared to MRI in augmented breasts. *CT scan* - **CT scans** are not routinely used for primary breast cancer screening due to their use of **ionizing radiation** and lower sensitivity for detecting early breast lesions compared to MRI. - CT is more commonly used for **staging** advanced cancers or evaluating complex masses detected by other modalities. *USG* - **Ultrasound (USG)** is a valuable complementary tool, especially for evaluating palpable lumps or clarifying findings from mammography, but it is **operator-dependent** and has a lower overall sensitivity for general screening compared to MRI. - It is particularly useful for differentiating between **cystic and solid masses** and detecting implant ruptures but is not the gold standard for comprehensive screening in augmented breasts.
Question 4: On mammogram, all of the following are the features of a malignant tumor except:
- A. Microcalcification
- B. Irregular mass
- C. Macrocalcification (Correct Answer)
- D. Spiculation
Explanation: ***Macrocalcification*** - **Macrocalcifications** are typically **benign** and are often associated with involutional changes in the breast, such as aging or fibroadenomas. - These are usually larger, coarser calcifications that are easily seen and rarely indicate malignancy. *Microcalcification* - **Microcalcifications**, especially when **pleomorphic**, **linear**, or grouped, are a significant indicator of potential malignancy, such as **ductal carcinoma in situ (DCIS)**. - They represent calcium deposits within the ducts or stromal tissue, which can be associated with rapidly proliferating cells. *Irregular mass* - An **irregularly shaped mass** with ill-defined margins is highly suspicious for malignancy because it suggests invasive growth into surrounding tissues. - Unlike benign lesions which tend to be round or oval with smooth borders, malignant tumors often grow in an uncontrolled, infiltrative manner. *Spiculation* - **Spiculation** refers to **radiating lines or projections** extending from the borders of a mass, indicating an infiltrative process highly suggestive of malignancy. - These spicules represent fibrous tissue reaction to an invading tumor and are a strong predictor of breast cancer.
Question 5: Most common complication of mastectomy is:
- A. Seroma (Correct Answer)
- B. Hemorrhage
- C. Infection
- D. Lymphedema
Explanation: ***Seroma*** - **Seroma** formation is the most common complication after mastectomy, involving the accumulation of serous fluid in the surgical dead space. - This complication can lead to discomfort, delayed wound healing, and an increased risk of infection. *Hemorrhage* - While a serious complication, **hemorrhage** is less common than seroma formation. - Significant hemorrhage usually occurs intraoperatively or in the immediate postoperative period and is typically managed promptly. *Lymphedema* - **Lymphedema** is a chronic condition characterized by swelling of the arm due to impaired lymphatic drainage, often developing months to years after surgery. - Although highly significant and debilitating, its incidence is lower than acute complications like seroma. *Infection* - Surgical site **infection** is a potential complication but is generally less frequent than seroma due to careful aseptic techniques and prophylactic antibiotics. - Infections can range from superficial wound infections to more serious cellulitis.
Question 6: Best investigation to detect rupture of silicone breast implants is-
- A. Mammography
- B. X-ray
- C. MRI (Correct Answer)
- D. USG
Explanation: ***MRI*** - **Magnetic Resonance Imaging (MRI)** is considered the **gold standard** for detecting silicone breast implant ruptures due to its superior soft tissue contrast and ability to differentiate silicone from other tissues. - It can accurately identify both **intracapsular** (linguine sign) and **extracapsular** ruptures, as well as associated silicone granulomas. *Mammography* - While useful for breast cancer screening, **mammography** has limited sensitivity for detecting silicone implant ruptures, especially subtle ones. - It can show indirect signs like implant contour abnormalities or increased implant density but is often inconclusive for rupture diagnosis. *X-ray* - **X-rays** provide very little information regarding the integrity of silicone breast implants because silicone is radiolucent and does not show up clearly on standard radiographs. - Its utility is primarily for detecting calcifications or foreign bodies, not implant rupture. *USG* - **Ultrasound (USG)** can be a useful initial screening tool for detecting implant ruptures, showing signs like the **"stepladder sign"** for intracapsular rupture or anechoic collections (silicone outside the capsule). - However, its accuracy is highly operator-dependent, and it may miss subtle ruptures or be limited by poor visualization due to scar tissue, making MRI a more definitive choice.
Question 7: Which of the following is the most sensitive investigation for ductal carcinoma in situ (DCIS) of the breast?
- A. PET Scan
- B. Ultrasound
- C. Mammography (Correct Answer)
- D. MRI
Explanation: ***Mammography*** - **Mammography** is the **gold standard** and **primary imaging modality** for detecting **ductal carcinoma in situ (DCIS)**, primarily because it excels at visualizing **microcalcifications**, which are the hallmark of DCIS. - Approximately **80-90% of DCIS cases** present as **microcalcifications** on mammograms, making it the most important screening and diagnostic tool. - Mammography has **high sensitivity (85-95%)** for detecting DCIS, especially calcified forms, and is widely available and cost-effective. *MRI* - While **MRI** has high sensitivity for invasive breast cancer and can detect non-calcified DCIS, it is **not the primary screening tool** for DCIS detection. - MRI is typically used for **staging known DCIS**, evaluating **extent of disease**, detecting **additional foci**, and screening **high-risk patients**. - However, MRI has lower specificity and higher false-positive rates compared to mammography, limiting its use as a primary diagnostic tool. *PET Scan* - **PET scans** are generally **not sensitive** for detecting **DCIS** because DCIS lesions typically have a **low metabolic rate** and do not avidly take up the **FDG tracer**. - PET scans are primarily used for detecting **invasive cancers** and assessing **metastatic disease**, not for non-invasive lesions like DCIS. *Ultrasound* - **Ultrasound** has **limited sensitivity** for detecting **DCIS** because DCIS often does not present as a palpable mass or a distinct sonographic abnormality. - While ultrasound can be useful for evaluating palpable masses or guiding biopsies, it frequently **misses microcalcifications** that are characteristic of DCIS. - Ultrasound is mainly used as a **complementary tool** to mammography, not as a primary diagnostic modality for DCIS.
Question 8: A middle aged male patient presents with painless slow growing neck swelling. On examination, lymph nodes are positive. Surgery is done and biopsy is shown in the image below. Which of the following is false regarding the HPE findings?
- A. Spread is through lymphatics
- B. Nuclear features are the characteristic of this tumor
- C. FNAC is not diagnostic (Correct Answer)
- D. It has excellent prognosis
Explanation: ***Fine needle aspiration cytology (FNAC) is not diagnostic*** - FNAC can often provide significant insights, but in cases of **specific malignancies** or certain lesions, it may not yield definitive diagnoses [1]. - Diagnostic challenges arise as **cellular architecture** or certain **nuclear features** may not be appreciated in FNAC samples [1]. *It spreads quickly via lymphatics* - This condition can indeed spread via lymphatics, making it **aggressive** in nature [1]. - **Lymphatic spread** is a common pathway for many head and neck conditions, particularly malignancies [1]. *Excellent prognosis is associated with this condition* - While some conditions may have favorable prognoses, many midline neck lesions can have **serious implications** depending on their nature [1]. - Prognosis often varies widely and may not always be classified as **excellent** based solely on initial presentation [1]. *Nuclear characteristics are used for the identification* - Nuclear morphology is critical for identifying various **neoplastic conditions**, aiding in differentiation from benign lesions [1][2]. - Many pathologies, especially those involving **malignancy**, rely heavily on **nuclear features** for accurate diagnosis [1][2]. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Endocrine System, pp. 1101-1102. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Endocrine System, pp. 1100-1101.
Question 9: Which of the following are correct in the treatment of cracked nipple? I. Correct attachment (Latch on) will provide immediate relief from pain and rapid healing. II. If pain, mother should use breast pump and the infant is fed with the expressed milk. III. Antifungal medication (such as miconazole or nystatin) is applied to treat both the mother's nipple and the baby's mouth if there is oral thrush. Select the answer using the code given below:
- A. I, II and III (Correct Answer)
- B. I and III only
- C. II and III only
- D. I and II only
Explanation: ***I, II and III*** - All three statements provide accurate and essential interventions for managing **cracked nipples** in breastfeeding mothers. - **Correct latch-on** is fundamental to prevention and healing, expressing milk can provide relief and maintain supply, and **antifungal treatment** is indicated if candidiasis is suspected in both mother and infant. *I and III only* - This option incorrectly omits statement II, which describes a valid and often necessary intervention for managing pain and ensuring continued feeding. - Using a **breast pump** allows the nipple to rest and heal while the infant still receives breast milk. *II and III only* - This option incorrectly omits statement I, which highlights the crucial role of **correct attachment (latch-on)** as the primary solution for preventing and healing cracked nipples. - Without addressing the latch, other interventions may only provide temporary relief. *I and II only* - This option incorrectly omits statement III, which addresses the potential for **candidiasis (thrush)** as a cause of nipple pain and cracking. - If thrush is present, antifungal treatment of both mother and baby is necessary for resolution.
Question 10: A patient of road traffic accident presents to the emergency with increasing restlessness and difficulty in breathing. The respiratory rate is 26 breaths/minute; there are distended neck veins; trachea is deviated to the right side with hyper-resonant note and absence of breath sounds on the left side. Which of the following statements are correct? 1. The most probable clinical diagnosis is left tension pneumothorax 2. Immediate chest decompression using wide bore cannula in left 2nd intercostal space is to be done 3. Immediate chest X-ray should be done to confirm the clinical diagnosis 4. Definitive chest tube insertion in left fifth intercostal space should be done
- A. 2, 3 and 4
- B. 1, 2 and 4 (Correct Answer)
- C. 1, 2 and 3
- D. 1, 3 and 4
Explanation: ***1, 2 and 4*** - The clinical presentation with **increasing restlessness**, **difficulty in breathing**, **distended neck veins**, **tracheal deviation away from the affected side** (to the right for a left-sided collection), **hyper-resonant note**, and **absent breath sounds on the left** is pathognomonic for **left tension pneumothorax** (Statement 1 is correct). - **Immediate needle decompression** with a wide-bore cannula in the **2nd intercostal space** along the mid-clavicular line on the affected side is a **life-saving intervention** that must be performed immediately (Statement 2 is correct). - After needle decompression, **definitive chest tube insertion** in the **5th intercostal space** (mid-axillary line) should be performed (Statement 4 is correct). - Statement 3 is **incorrect** because tension pneumothorax is a **clinical diagnosis** requiring immediate treatment without delaying for imaging, which could be fatal. *2, 3 and 4* - This combination is incorrect because Statement 3 is wrong. - **Immediate chest X-ray should NOT be done** for suspected tension pneumothorax as it is a **clinical emergency** requiring immediate decompression without delay for imaging. - Statement 1 (the correct diagnosis) is also missing from this option. *1, 2 and 3* - This combination is incorrect because Statement 3 is wrong. - **Delaying treatment to obtain imaging** can be **fatal** due to cardiovascular collapse from mediastinal shift and impaired venous return. - Statement 4 (definitive chest tube insertion) is also missing from this option. *1, 3 and 4* - This combination is incorrect because Statement 3 is wrong. - The diagnosis is **clinical**, and treatment (needle decompression - Statement 2) should be initiated immediately to prevent hemodynamic compromise and death. - Statement 2 (immediate needle decompression) is also missing from this option.
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