Pharmacokinetics and Pharmacodynamics Practice Questions

Question 1

A factor that is likely to increase the duration of action of a drug that is partially metabolized by CYP3A4 in the liver is:

Accepted Answer

Chronic administration of cimetidine with the drug

Answer

Chronic administration of phenobarbital with the drug

Answer

Displacement from tissue binding sites by another drug

Answer

Chronic administration of rifampicin

Question 2

Which of the following factors influences the duration of action of a drug?

Accepted Answer

All of the options

Answer

Bioavailability

Answer

Clearance

Answer

Rate of elimination

Question 3

A 70 kg man was given a drug with a dose of 100 mg/kg body weight, twice daily. The half-life (t1/2) is 10 hours, the plasma concentration is 1.9 mg/mL, and the clearance is unknown. What is the clearance of this drug?

Accepted Answer

0.22 L/hr

Answer

20 liter/hr

Answer

K is 0.0693

Answer

0.02 L/hr

Question 4

All of the following statements regarding the bioavailability of a drug are true except which one?

Accepted Answer

Low oral availability always and necessarily means poor absorption

Answer

It is a fraction of administered drug that reaches the systemic circulation in unchanged form

Answer

Bioavailability can be determined from plasma concentration or urinary excretion data.

Answer

Bioavailability of an orally administered drug can be calculated by comparing the Area Under Curve after oral and intravenous administration

Question 5

Which of the following actions is NOT associated with tricyclic antidepressants?

Accepted Answer

MAO inhibition

Answer

Block 5-HT or NE reuptake

Answer

Anticholinergic action

Answer

Causes sedation

Question 6

With which of the following receptors does theophylline have an antagonistic interaction?

Accepted Answer

Adenosine receptors

Answer

Histamine receptors

Answer

Imidazoline receptors

Answer

Bradykinin receptors

Question 7

Clozapine is used in:

Accepted Answer

Resistant schizophrenia

Answer

Depression

Answer

Mania

Answer

Delirium

Question 8

Which antipsychotic has anti-suicidal properties?

Accepted Answer

clozapine

Answer

chlorpromazine

Answer

aripiprazole

Answer

amisulpride

Question 9

Use of lithium in pregnancy can result in which of the following abnormalities in the baby?

Accepted Answer

Ebstein's anomaly

Answer

Anencephaly

Answer

Caudal dysgenesis syndrome

Answer

Elfin facies

Question 10

Which of the following antipsychotic medications carries the least risk of metabolic side effects?

Accepted Answer

Ziprasidone

Answer

Risperidone

Answer

Olanzapine

Answer

Clozapine

Pharmacokinetics and Pharmacodynamics — MCQs

Pharmacokinetics and Pharmacodynamics — MCQs

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