OCD Spectrum Disorders — MCQs
Body dysmorphic disorder can be associated with all except
A patient presents with compulsive hair pulling resulting in irregular patchy hair loss. What is the most likely diagnosis?
Brain areas involved with obsessive compulsive disorder include all except:
Chronic disorder characterized by compulsive use of drugs, resulting in physical, psychological, and social harm, and continued use despite evidence that it is harmful is called.
Trichophagia is characterized by?
In obsessive-compulsive disorder, which medication is NOT used for treatment?
Which of the following is not classified as OCD as per ICD 11?
An 18-year-old girl presents with a circumscribed bald patch. There is no evidence of organic disease. What is the most likely diagnosis?
A 40-year-old teacher reports excessive handwashing, counting rituals, and difficulty in completing daily tasks. She believes these actions prevent harm to her students. What is the diagnosis?
Drug of choice for obsessive-compulsive disorder is:
OCD Spectrum Disorders Indian Medical PG Practice Questions and MCQs
Question 1: Body dysmorphic disorder can be associated with all except
- A. Bulimia nervosa
- B. OCD
- C. Anxiety
- D. Mania (Correct Answer)
Explanation: ***Mania*** - **Mania** is a state of elevated, expansive, or irritable mood that is distinct from the persistent preoccupation with perceived bodily defects seen in **body dysmorphic disorder (BDD)**. - While agitation can occur in BDD, the core symptom profile of **mania**, including decreased need for sleep, grandiosity, and racing thoughts, is not a typical associated feature. *Bulimia nervosa* - **Bulimia nervosa** can co-occur with BDD, particularly when the perceived defects relate to body weight, shape, or specific body parts. - Both disorders involve intense preoccupation with body image and often lead to harmful behaviors to attempt to "correct" perceived flaws. *OCD* - **Obsessive-compulsive disorder (OCD)** shares strong phenomenological similarities with BDD, including intrusive thoughts (obsessions) and repetitive behaviors (compulsions). - BDD is often conceptualized as part of the **OCD spectrum**, with both disorders involving obsessive thoughts and repetitive behaviors related to specific concerns. *Anxiety* - **Anxiety disorders** are highly comorbid with BDD, as individuals often experience significant distress, fear of judgment, and social avoidance due to their perceived flaws. - The constant preoccupation and efforts to conceal or fix perceived defects can lead to chronic anxiety and panic attacks.
Question 2: A patient presents with compulsive hair pulling resulting in irregular patchy hair loss. What is the most likely diagnosis?
- A. Trichotillomania (Correct Answer)
- B. Alopecia areata
- C. Telogen effluvium
- D. Tinea infection
Explanation: ***Trichotillomania*** - This condition is characterized by **recurrent, irresistible urges to pull out hair**, typically resulting in **noticeable hair loss**. - The resulting patchy hair loss is often **irregular** and can occur in various areas, aligning with the patient's presentation. *Alopecia areata* - This is an **autoimmune condition** that causes smooth, **well-demarcated patches of hair loss**, not typically associated with compulsive pulling. - It usually presents with a sudden onset of hair loss without any preceding trauma or manipulation. *Telogen effluvium* - This condition involves **widespread hair thinning** due to a disturbance in the hair growth cycle, often triggered by stress or illness. - It does not involve compulsive hair pulling and typically results in increased hair shedding rather than patchy hair loss. *Tinea infection* - Also known as **ringworm**, this is a fungal infection that can cause **scaly, itchy patches of hair loss**, sometimes with inflammation and broken hairs. - While it can cause patchy hair loss, it is characterized by dermatological signs of infection (e.g., scaling, erythema) and not compulsive hair pulling.
Question 3: Brain areas involved with obsessive compulsive disorder include all except:
- A. Head of caudate nucleus
- B. Corpus callosum (Correct Answer)
- C. Orbitofrontal cortex
- D. Basal ganglia
Explanation: ***corpus callosum*** - The **corpus callosum** is primarily involved in **interhemispheric communication**, connecting the two cerebral hemispheres, and is not a core area implicated in the pathophysiology of **OCD**. - While damage to the corpus callosum can lead to neurological deficits, it is not directly associated with the obsessions and compulsions seen in OCD. *Head of caudate nucleus* - The **caudate nucleus**, particularly its head, is part of the **basal ganglia** and is highly implicated in **OCD**, with studies showing abnormal activity and volume. - It plays a crucial role in **goal-directed behavior** and **habit formation**, which are dysfunctional in OCD. *Orbitofrontal cortex* - The **orbitofrontal cortex (OFC)** is consistently identified in neuroimaging studies as being hyperactive in individuals with **OCD**. - It is involved in **decision-making**, **reward processing**, and **emotional regulation**, contributing to the characteristic symptoms of OCD. *Basal ganglia* - The **basal ganglia**, a group of subcortical nuclei including the **caudate nucleus**, **putamen**, and **globus pallidus**, are central to the neurocircuitry of **OCD**. - This region is critical for **motor control**, **habit learning**, and **executive functions**, and its dysfunction is thought to contribute to the repetitive behaviors and cognitive rigidity seen in OCD.
Question 4: Chronic disorder characterized by compulsive use of drugs, resulting in physical, psychological, and social harm, and continued use despite evidence that it is harmful is called.
- A. Substance intoxication
- B. Drug addiction (Correct Answer)
- C. Drug abuse
- D. Drug dependence
Explanation: ***Drug addiction*** - This definition accurately describes **drug addiction** as a chronic disorder involving compulsive drug use despite harmful consequences across physical, psychological, and social domains. - Key components include the **compulsive nature** of use, the **harmful outcomes**, and the persistence of use even with awareness of these harms. *Substance intoxication* - **Substance intoxication** refers to the acute, reversible effects of a substance on the central nervous system, leading to clinical changes in perception, mood, and behavior. - It does not encompass the chronic, compulsive use or the long-term physical, psychological, and social harms characteristic of addiction. *Drug abuse* - **Drug abuse** is a pattern of harmful use of a psychoactive substance, but it doesn't necessarily include the compulsive, chronic nature and the concept of continued use despite acknowledging harm that defines addiction. - The term "abuse" is often considered outdated in favor of "substance use disorder" in clinical contexts to better reflect the chronic disease model. *Drug dependence* - **Drug dependence** refers to a physiological state where the body adapts to a substance, leading to **withdrawal symptoms** if the substance is stopped and **tolerance** to its effects. - While it is a component of addiction, it does not fully capture the compulsive drug-seeking behavior or the broader psychological and social harms that define addiction itself.
Question 5: Trichophagia is characterized by?
- A. Compulsive pulling of hair
- B. Compulsive eating of hair (Correct Answer)
- C. Compulsive shopping
- D. Compulsive stealing
Explanation: ***Compulsive eating of hair*** - **Trichophagia** is the **compulsive eating of hair** and is often associated with trichotillomania (compulsive hair pulling). - In severe cases, ingested hair can form a **bezoar** (hairball) in the gastrointestinal tract, known as **Rapunzel syndrome**. *Compulsive pulling of hair* - This describes **trichotillomania**, a distinct body-focused repetitive behavior. - While frequently co-occurring with trichophagia, it specifically refers to the act of **pulling out hair**, not eating it. *Compulsive shopping* - This is an impulse control disorder characterized by an **uncontrollable urge to shop**, distinct from behaviors involving hair. - It is often associated with **financial, social, and emotional problems**. *Compulsive stealing* - This is known as **kleptomania**, an impulse control disorder characterized by an **irresistible urge to steal objects** that are often not needed for personal use or monetary value. - It is unrelated to hair-focused behaviors.
Question 6: In obsessive-compulsive disorder, which medication is NOT used for treatment?
- A. Sertraline
- B. Clomipramine
- C. Carbamazepine (Correct Answer)
- D. Haloperidol
Explanation: ***Carbamazepine*** - **Carbamazepine** is an **anticonvulsant** and **mood stabilizer** primarily used for **epilepsy** and **bipolar disorder**. - It does not have a primary role in the treatment of **obsessive-compulsive disorder (OCD)**. *Sertraline* - **Sertraline** is a **selective serotonin reuptake inhibitor (SSRI)** approved for **OCD** treatment. - SSRIs are considered **first-line pharmacological agents** for OCD due to their efficacy in reducing obsessive thoughts and compulsive behaviors. *Clomipramine* - **Clomipramine** is a **tricyclic antidepressant (TCA)** that is a potent **serotonin reuptake inhibitor**. - It is one of the **most effective medications for OCD** and has been historically used as a first-line treatment. *Haloperidol* - **Haloperidol**, an **antipsychotic**, can be used as an **augmentation strategy** for OCD that is **resistant to SSRI treatment**. - It may be particularly helpful in OCD presentations with **comorbid tic disorders** or significant behavioral disinhibition.
Question 7: Which of the following is not classified as OCD as per ICD 11?
- A. Hypochondriac disorder
- B. Body dysmorphic disorder
- C. PTSD (Correct Answer)
- D. Trichotillomania
Explanation: ***PTSD*** - **Post-traumatic stress disorder (PTSD)** is classified under **disorders specifically associated with stress** in ICD-11, not as an OCD-related disorder. - PTSD involves symptoms like re-experiencing the traumatic event, avoidance, and hyperarousal following exposure to a **traumatic event**. *Hypochondriac disorder* - In ICD-11, **hypochondriac disorder (illness anxiety disorder)** is reclassified under **obsessive-compulsive or related disorders**, focusing on preoccupation with having a serious illness. - This reflects the **compulsive checking** and **obsessive fears** associated with the condition. *Body dysmorphic disorder* - **Body dysmorphic disorder** is classified under **obsessive-compulsive or related disorders** in ICD-11. - It is characterized by **preoccupation with perceived flaws in physical appearance** and repetitive behaviors (e.g., mirror checking) in response to these concerns. *Trichotillomania* - **Trichotillomania (hair-pulling disorder)** is classified as an **obsessive-compulsive or related disorder** in ICD-11. - It involves **recurrent pulling out of one's hair** resulting in hair loss, despite repeated attempts to stop.
Question 8: An 18-year-old girl presents with a circumscribed bald patch. There is no evidence of organic disease. What is the most likely diagnosis?
- A. Depression
- B. OCD
- C. Phobia
- D. Trichotillomania (Hair-Pulling Disorder) (Correct Answer)
Explanation: ***Trichotillomania (Hair-Pulling Disorder)*** - This condition is characterized by the **recurrent pulling out of one's hair**, resulting in noticeable hair loss or **bald patches**. - The description of a **circumscribed bald patch** without evidence of organic disease in an 18-year-old girl is highly suggestive of trichotillomania, especially given that organic causes of hair loss have been ruled out. *Depression* - While depression can be a **comorbid condition** with trichotillomania, it does not directly cause a circumscribed bald patch. - Depression is a **mood disorder** primarily characterized by persistent sadness, loss of interest, and other emotional and physical symptoms. *OCD* - **Obsessive-compulsive disorder** (OCD) involves intrusive thoughts (obsessions) and repetitive behaviors (compulsions). - Although trichotillomania can share some characteristics with OCD (e.g., repetitive behavior), it is classified as a distinct **body-focused repetitive behavior disorder** in the DSM-5, not OCD itself. *Phobia* - A phobia is an **anxiety disorder** defined by an intense and irrational fear of a specific object or situation. - Phobias do not directly cause **physical symptoms** like bald patches; their primary manifestation is avoidance and panic in the presence of the feared stimulus.
Question 9: A 40-year-old teacher reports excessive handwashing, counting rituals, and difficulty in completing daily tasks. She believes these actions prevent harm to her students. What is the diagnosis?
- A. Generalized anxiety disorder
- B. Obsessive-compulsive disorder (Correct Answer)
- C. Paranoid schizophrenia
- D. Phobic disorder
Explanation: ***Obsessive-compulsive disorder*** - The patient's presentation of **recurrent, intrusive thoughts** (worries about students' harm) and **repetitive behaviors** (excessive handwashing, counting rituals) performed to reduce anxiety or prevent a dreaded event is characteristic of OCD. - The individual recognizes that these obsessions or compulsions are **excessive or unreasonable**, causing significant distress and impairment in daily functioning. *Generalized anxiety disorder* - This disorder is characterized by **persistent and excessive worry** about various aspects of life, not typically focused on specific, intrusive obsessions leading to compulsive rituals. - While anxiety is present, it does not manifest as specific **compulsive behaviors** performed in response to obsessions. *Paranoid schizophrenia* - Schizophrenia involves **psychotic symptoms** such as delusions (fixed false beliefs, often persecutory), hallucinations, disorganized speech, and negative symptoms. - The patient's symptoms are not indicative of a thought disorder, delusions, or hallucinations but rather anxiety-driven, repetitive behaviors. *Phobic disorder* - **Phobic disorders** involve intense, irrational fear of specific objects or situations (e.g., social phobia, specific phobia). - The patient's symptoms are not primarily triggered by a specific phobic stimulus but rather by intrusive thoughts leading to ritualistic behaviors.
Question 10: Drug of choice for obsessive-compulsive disorder is:
- A. Sertraline
- B. Fluoxetine (Correct Answer)
- C. Alprazolam
- D. Chlorpromazine
Explanation: ***Fluoxetine*** - **Selective serotonin reuptake inhibitors (SSRIs)** are the first-line pharmacological treatment for **obsessive-compulsive disorder (OCD)**. - **Fluoxetine** was traditionally considered a primary choice for OCD treatment and is FDA-approved for this indication. - It works by selectively inhibiting serotonin reuptake, increasing serotonergic neurotransmission, which is crucial in OCD pathophysiology. - Higher doses are typically required for OCD compared to depression (40-80 mg/day). *Sertraline* - **Sertraline** is also an **SSRI** and equally effective as fluoxetine for OCD treatment. - It is FDA-approved for OCD and considered a first-line option. - In current clinical practice, **all SSRIs (fluoxetine, sertraline, fluvoxamine, paroxetine) are considered equally appropriate first-line choices** with no single "drug of choice." - Selection depends on individual patient factors, side effect profile, and drug interactions. - **Note:** Both fluoxetine and sertraline are correct answers in modern practice; this question reflects historical exam teaching. *Alprazolam* - **Alprazolam** is a **benzodiazepine** used for short-term relief of anxiety and panic attacks. - It does not address the core pathophysiology of OCD (obsessions and compulsions). - Not recommended as monotherapy for OCD; may be used adjunctively for severe anxiety symptoms. *Chlorpromazine* - **Chlorpromazine** is a **first-generation antipsychotic** used primarily for schizophrenia and psychotic disorders. - Not indicated for OCD treatment as monotherapy. - Antipsychotics may be used as **augmentation** in treatment-resistant OCD but only as add-on to SSRIs.
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