FMGE 2018 Practice Questions

Q: Essential fatty acid:

Linoleic acid. ***Linoleic acid*** - **Linoleic acid** is an **omega-6 fatty acid** that is considered essential because the human body cannot synthesize it and must obtain it through diet. - It is a precursor for other important fatty acids like **arachidonic acid**, which are involved in inflammation and blood clotting. *Citric acid* - **Citric acid** is an organic acid found in citrus fruits and is a key intermediate in the **Krebs cycle** (citric acid cycle), a central metabolic pathway, but it is not a fatty acid. - It is readily synthesized by the body and is therefore not considered an essential nutrient. *Palmitic acid* - **Palmitic acid** is a **saturated fatty acid** with 16 carbon atoms, which is the most common fatty acid in animals and plants. - It can be synthesized by the human body from excess carbohydrates and proteins, hence it is not an essential fatty acid. *Stearic acid* - **Stearic acid** is another common **saturated fatty acid** with 18 carbon atoms, found in various animal and plant fats. - Like palmitic acid, it can be endogenously synthesized by the body and is not considered essential.

Q: All are premalignant conditions of oral cavity except:

Oral lichen planus. ***Oral lichen planus*** - While certain forms of **oral lichen planus (OLP)**, particularly the erosive type, are considered to have a small potential for malignant transformation, it is generally considered a **potentially malignant disorder** rather than a definitively premalignant condition with high rates of progression. - Its transformation rates are significantly lower and less consistent across studies compared to other conditions listed. *Oral submucosal fibrosis* - This is a well-established **premalignant condition** characterized by chronic, progressive fibrotic changes in the oral mucosa, primarily due to **areca nut chewing**. - It has a high malignant transformation rate, particularly into **oral squamous cell carcinoma**. *Leucoplakia* - This is defined as a white plaque of the oral mucosa that cannot be rubbed off and cannot be characterized as any other diagnosable disease. - It is histologically often associated with **epithelial dysplasia** and has a significant risk of developing into **oral squamous cell carcinoma**, making it a definitive premalignant condition. *Chronic hyperplastic candidiasis* - This is a form of **mucocutaneous candidiasis** that presents as a persistent white plaque that cannot be scraped off. - Unlike other forms of candidiasis, it is considered a **premalignant lesion** with a potential for malignant transformation, especially if associated with epithelial dysplasia.

Q: Dip at 4000 Hz in pure tone audiometry indicates:

Noise induced hearing loss. ***Noise induced hearing loss*** - A characteristic **"4 kHz Notch"** or dip in the audiogram is a hallmark of **noise-induced hearing loss**, resulting from damage to the **cochlear hair cells** in this frequency range. - This specific frequency is most susceptible to damage from loud noise exposure due to the physical properties of the **basilar membrane**. *Meniere's disease* - Typically presents with **low-frequency hearing loss**, often fluctuating, along with **tinnitus**, **vertigo**, and a feeling of **aural fullness**. - A dip at 4000 Hz is not a characteristic audiometric finding for **Meniere's disease**. *Age related hearing loss* - Also known as **presbycusis**, it is typically a **symmetrical, progressive, sensorineural hearing loss** that primarily affects **higher frequencies**, but it usually presents as a more gradual slope rather than a sharp dip at a specific frequency like 4 kHz. - While high frequencies are affected, the pattern is usually a broader high-frequency loss, not an isolated notch. *Otosclerosis* - This condition is a form of **conductive hearing loss** (though it can have a sensorineural component in advanced stages) due to abnormal bone growth around the **stapes footplate**. - Its classic audiometric finding is a **Carhart notch** around 2000 Hz, with a conductive hearing loss pattern, rather than a sensorineural dip at 4000 Hz.

Q: 35 years old female presents with tinnitus, vertigo and aural fullness. Likely diagnosis:

Meniere's Disease. ***Meniere's Disease*** - The classic triad of symptoms for Meniere's disease includes **tinnitus**, **vertigo**, and **aural fullness**, along with fluctuating sensorineural hearing loss. - This condition is thought to be caused by an excess of **endolymphatic fluid** within the inner ear. *Ototoxicity* - This condition typically presents with **bilateral, symmetrical hearing loss** and tinnitus, often induced by certain medications (e.g., aminoglycosides, aspirin in high doses). - It usually does not involve episodic vertigo or aural fullness, which are characteristic of Meniere's. *Noise Induced Hearing Loss* - Characterized primarily by **permanent sensorineural hearing loss**, often at specific frequencies (e.g., 4000 Hz notch), and **tinnitus** after prolonged exposure to loud noise. - It does not typically cause the episodic vertigo or sense of aural fullness seen in Meniere's disease. *Otosclerosis* - This condition causes **progressive conductive hearing loss** due to abnormal bone growth around the stapes bone, impairing its movement. - While it can cause tinnitus, it typically does not present with vertigo or aural fullness, and the primary hearing loss is conductive, not sensorineural.

Q: True about Mooren's ulcer:

Affects cornea. ***Affects cornea*** - **Mooren's ulcer** is a rare, severe, and idiopathic chronic **ulcerative keratitis** that primarily affects the cornea. - It involves a progressive **peripheral corneal stromal thinning** and ulceration, often extending circumferentially and centrally. *Bilateral in majority of cases* - Mooren's ulcer is **unilateral in approximately 60-80%** of cases, making bilateral presentation less common. - While it can be bilateral, especially in a more severe form, it's not the majority presentation. *Sudden loss of vision* - The vision loss associated with Mooren's ulcer is typically **gradual and progressive**, due to increasing corneal thinning, scarring, and astigmatism. - **Sudden vision loss** is not a characteristic feature of this condition and would suggest other acute pathologies. *Painless* - Mooren's ulcer is often associated with **significant pain**, **photophobia**, and **lacrimation**. - The pain can be severe and debilitating, stemming from the inflammatory process and corneal nerve involvement.

Q: True for lithium:

Narrow therapeutic index. ***Narrow therapeutic index*** - Lithium has a **narrow therapeutic index**, meaning the difference between its effective and toxic doses is small. - This necessitates **close monitoring of serum lithium levels** to ensure efficacy and prevent toxicity. *Can be given safely in renal dysfunction* - Lithium is **primarily excreted renally**, and its clearance is directly proportional to creatinine clearance. - Therefore, it **should be used with caution** (or avoided) in patients with renal dysfunction due to increased risk of toxicity. *Protein bound* - Lithium is **not protein-bound**; it exists as a free ion in the blood. - This characteristic contributes to its rapid distribution and excretion. *Delayed absorption* - Lithium is **rapidly and almost completely absorbed** from the gastrointestinal tract. - Peak plasma concentrations are usually reached within 1-2 hours for immediate-release preparations.

Q: An exaggerated pain response to a normally painful stimulus is called:

Hyperalgesia. ***Hyperalgesia*** - This term describes an **increased sensitivity to pain** where a stimulus that is normally painful is perceived as even more painful than usual. - It often results from **damage to nociceptive afferent pathways** or central sensitization. *Causalgia* - This is an older term now largely replaced by complex regional pain syndrome type II (**CRPS II**), characterized by severe, burning pain following a **nerve injury**. - Unlike hyperalgesia, it specifically refers to a **syndrome of severe pain** after nerve trauma, not just an increased response to noxious stimuli. *Allodynia* - This refers to pain caused by a stimulus that **does not normally provoke pain**, such as light touch or brushing of the skin. - It differs from hyperalgesia, which is an exaggerated response to a **normally painful stimulus**. *Hypersensitivity* - This is a **general term** meaning an increased physical or allergic sensitivity to a substance or condition. - It is a **broader concept** and not as specific to pain perception as hyperalgesia or allodynia.

Q: Dye for Sentinel Lymph Node Biopsy is injected in which of the following sites?

Areola. ***Areola*** - The **areola** is the primary site for injecting dye in sentinel lymph node biopsy because it is rich in **lymphatic vessels** that directly drain into the regional lymph nodes. - This method ensures the dye follows the natural lymphatic drainage pathway, accurately identifying the **first lymph node** to receive drainage from the tumor. *Nipple* - While the nipple is part of the breast, it has a less dense network of **lymphatic vessels** compared to the areola. - Injection directly into the nipple may not consistently identify the sentinel lymph node as effectively as periareolar or intratumoral injections. *Axilla* - The **axilla** contains the regional lymph nodes that are the *target* for identification, not the site of dye injection. - Injecting dye directly into the axilla would bypass the lymphatic drainage from the tumor, making the biopsy ineffective. *Tail of spence* - The **tail of Spence** is an extension of breast tissue into the axilla, and while it contains breast tissue, it is not the most optimal or primary site for dye injection. - The lymphatic drainage from the tail of Spence would still rely on the broader lymphatic network, which is best accessed via the central breast regions like the areola.

Q: Which of the following is not done in carcinoma esophagus?

pH - metry/monitoring. ***pH - metry/monitoring*** - **pH metry/monitoring** is primarily used to diagnose **gastroesophageal reflux disease (GERD)**, which is not a direct diagnostic tool for esophageal carcinoma itself. - While GERD is a risk factor for **Barrett's esophagus** and subsequently adenocarcinoma of the esophagus, pH monitoring does not directly identify or stage the cancer. *CT chest* - **CT (Computed Tomography) chest** is routinely performed in esophageal carcinoma to assess the **local extent** of the tumor and identify potential **lymph node involvement** or **metastasis** to other organs. - It is crucial for **staging** the disease and guiding treatment decisions such as resectability. *PET scan* - A **PET (Positron Emission Tomography) scan** is highly useful for detecting **distant metastases** and identifying **occult disease** not visible on CT, especially in cases of suspected advanced esophageal carcinoma. - It helps in **accurate staging** and avoiding futile surgery in patients with metastatic disease. *Biopsy* - **Biopsy**, typically performed during endoscopy, is the **gold standard** for confirming the diagnosis of esophageal carcinoma by obtaining tissue for **histopathological examination**. - It identifies the cell type (e.g., adenocarcinoma, squamous cell carcinoma) and grade of the tumor, which is essential for treatment planning.

Question 1

Essential fatty acid:

Accepted Answer

Linoleic acid

Answer

Citric acid

Answer

Palmitic acid

Answer

Stearic acid

Question 2

All are premalignant conditions of oral cavity except:

Accepted Answer

Oral lichen planus

Answer

Oral submucosal fibrosis

Answer

Leucoplakia

Answer

Chronic hyperplastic candidiasis

Question 3

Dip at 4000 Hz in pure tone audiometry indicates:

Accepted Answer

Noise induced hearing loss

Answer

Meniere's disease

Answer

Age related hearing loss

Answer

Otosclerosis

Question 4

35 years old female presents with tinnitus, vertigo and aural fullness. Likely diagnosis:

Accepted Answer

Meniere's Disease

Answer

Ototoxicity

Answer

Noise Induced Hearing Loss

Answer

Otosclerosis

Question 5

True about Mooren's ulcer:

Accepted Answer

Affects cornea

Answer

Bilateral in majority of cases

Answer

Sudden loss of vision

Answer

Painless

Question 6

What is the mechanism of secondary healing?

Accepted Answer

Granulation tissue

Answer

Neovascularization

Answer

Scab formation

Answer

Granuloma formation

Question 7

True for lithium:

Accepted Answer

Narrow therapeutic index

Answer

Can be given safely in renal dysfunction

Answer

Protein bound

Answer

Delayed absorption

Question 8

An exaggerated pain response to a normally painful stimulus is called:

Accepted Answer

Hyperalgesia

Answer

Causalgia

Answer

Allodynia

Answer

Hypersensitivity

Question 9

Dye for Sentinel Lymph Node Biopsy is injected in which of the following sites?

Accepted Answer

Areola

Answer

Nipple

Answer

Axilla

Answer

Tail of spence

Question 10

Which of the following is not done in carcinoma esophagus?

Accepted Answer

pH - metry/monitoring

Answer

CT chest

Answer

PET scan

Answer

Biopsy

FMGE 2018

Biochemistry

Dental

ENT

Ophthalmology

Pathology

Pharmacology

Physiology

Surgery