FMGE 2018 Practice Questions

Q: Which bone connects the sternum to the scapula?

Clavicle. ***Clavicle*** - The **clavicle**, or collarbone, is the only bone that directly connects the **axial skeleton** (via the sternum) to the **appendicular skeleton** (via the scapula). - It articulates medially with the **manubrium** of the sternum at the sternoclavicular joint and laterally with the **acromion** of the scapula at the acromioclavicular joint. *First rib* - The **first rib** articulates with the **manubrium** of the sternum but does not connect directly to the scapula. - Its primary role is to form part of the **thoracic cage**, protecting internal organs. *Manubrium* - The **manubrium** is the superior part of the **sternum** and articulates with the clavicles and the first two ribs. - It does not directly connect to the **scapula**; rather, the clavicle mediates this connection. *Second rib* - The **second rib** articulates with both the **manubrium** and the body of the sternum at the **sternal angle**. - Like the first rib, it is part of the **thoracic cage** and does not directly connect to the scapula.

Q: Intellectual disability is seen in?

Phenylketonuria. ***Phenylketonuria*** - **Phenylketonuria (PKU)** is an inherited metabolic disorder where the body cannot process the amino acid **phenylalanine**, leading to its accumulation in the blood and brain. - Untreated PKU results in severe neurological problems, including **intellectual disability**, seizures, and developmental delays. *Von Gierke disease* - **Von Gierke disease** is a type of glycogen storage disease primarily affecting the liver and kidneys, causing **hypoglycemia** and **lactic acidosis**. - It does not typically involve intellectual disability; cognitive development is usually normal if metabolic complications are managed. *Alkaptonuria* - **Alkaptonuria** is an inherited disorder characterized by the accumulation of **homogentisic acid**, leading to dark urine, ochronosis (bluish-black discoloration of cartilage and connective tissue), and arthritis. - It does not cause intellectual disability. *Albinism* - **Albinism** is a group of inherited disorders characterized by a reduced or complete lack of **melanin pigment** in the skin, hair, and eyes. - While it causes vision problems, such as photosensitivity and nystagmus, it is not associated with intellectual disability.

Q: A patient presented with 2 days history of fever. On examination there was a swelling in the neck and one side tonsil was pushed to midline. What is the most likely diagnosis:-

Quinsy. ***Quinsy (Peritonsillar abscess)*** - **Quinsy** is a **peritonsillar abscess** that presents with fever, severe throat pain, and the pathognomonic sign of **unilateral tonsil pushed toward the midline**. - The abscess forms in the **peritonsillar space** (between the tonsillar capsule and superior constrictor muscle), causing **medial displacement of the tonsil** and **bulging of the soft palate**. - Patients typically have **trismus, dysphagia, "hot potato voice"** and may have visible neck swelling. - This clinical presentation exactly matches the description: tonsil pushed to midline is the **classic finding for peritonsillar abscess**. *Parapharyngeal abscess* - A **parapharyngeal abscess** involves the deep parapharyngeal space lateral to the pharynx. - While it can cause neck swelling and fever, it typically causes **fullness and induration of the lateral pharyngeal wall** rather than prominent medial displacement of the tonsil itself. - The **tonsil is usually NOT pushed to the midline** in parapharyngeal abscess; instead, there is lateral pharyngeal wall bulging. - Often presents with more prominent external neck swelling below the angle of mandible. *Retropharyngeal abscess* - A **retropharyngeal abscess** occurs in the retropharyngeal space behind the posterior pharyngeal wall. - Presents with **posterior pharyngeal wall bulge**, neck stiffness, and dysphagia. - Does **NOT cause medial displacement of the tonsil** as the abscess is posterior, not lateral to the tonsil. *Tonsillitis* - **Acute tonsillitis** causes bilateral tonsillar inflammation with erythema and exudates. - While both tonsils may be enlarged, there is **no unilateral medial displacement** of one tonsil. - Less likely to cause significant neck swelling compared to deep space infections.

Q: Which one of the following is a major component in activation of the complement alternative pathway?

C3. ***C3*** - **C3** is a central component in all complement pathways. In the alternative pathway, spontaneous hydrolysis of **C3** leads to C3(H2O), initiating the formation of the **C3 convertase**. - This **C3 convertase** (C3bBb) further cleaves more **C3** into C3a and C3b, amplifying the pathway and leading to downstream complement activation. *C2* - **C2** is a crucial component of the **classical** and **lectin pathways**, where it is cleaved by C1s or MASP-2, respectively, to form C2b and C2a. - **C2a** then combines with C4b to form the **C3 convertase** (C4b2a) of these pathways; it does not play a direct role in initiating the alternative pathway. *C4* - **C4** is primarily involved in the **classical** and **lectin pathways**, where it is cleaved by C1s or MASP-2 to form C4a and C4b. - **C4b** binds to pathogens or immune complexes and then associates with C2a to form the **C3 convertase** (C4b2a), which is not part of the alternative pathway initiation. *C1* - **C1** is the initiating complex of the **classical complement pathway** and is composed of C1q, C1r, and C1s. - It recognizes and binds to antibody-antigen complexes or pathogen surfaces, but it has no direct role in the **alternative pathway activation**.

Q: Campimetry is used to measure:

Field of Vision. ***Field of Vision*** - **Campimetry** is a diagnostic test specifically designed to map and assess a person's **field of vision**, identifying blind spots or areas of diminished sight. - This technique is crucial for detecting and monitoring conditions that affect the optic nerve or visual pathways, such as **glaucoma** or neurological disorders. *Squint* - A **squint**, also known as strabismus, refers to a misalignment of the eyes. - Its assessment primarily involves tests of **ocular motility** and alignment, such as the cover test, rather than perimetry. *Pattern of retina* - The **pattern of the retina** is evaluated through direct visualization using an **ophthalmoscope** or other retinal imaging techniques like fundus photography or optical coherence tomography (OCT). - These methods provide structural information about the retina, not its functional visual field. *Malignant melanoma* - **Malignant melanoma** (in the context of the eye) is a tumor that can affect various parts of the eye, including the choroid, iris, or conjunctiva. - Its diagnosis involves clinical examination, imaging studies (**ultrasound**, OCT, **fluorescein angiography**), and sometimes biopsy, not primarily visual field testing.

Q: Which of the following drugs is a direct inhibitor of clotting factor Xa?

Apixaban. ***Apixaban*** - Apixaban is an **oral direct factor Xa inhibitor**, which means it directly binds to and inactivates factor Xa. - This inhibition prevents the conversion of **prothrombin to thrombin**, thereby disrupting the coagulation cascade. *Argatroban* - Argatroban is a **direct thrombin inhibitor** (DTI), meaning it selectively binds to and inhibits thrombin (factor IIa). - It is often used in cases of **heparin-induced thrombocytopenia (HIT)** due to its non-heparin-based mechanism of action. *Fondaparinux* - Fondaparinux is an **indirect factor Xa inhibitor** that binds to antithrombin, thereby enhancing antithrombin's ability to inactivate factor Xa. - It does not directly bind to factor Xa itself, but rather potentiates the action of a natural anticoagulant. *Aspirin* - Aspirin is an **antiplatelet agent** that inhibits cyclooxygenase (COX-1), thereby reducing the production of thromboxane A2. - This mechanism primarily inhibits **platelet aggregation** and adhesion, rather than directly inhibiting a clotting factor in the coagulation cascade.

Q: Histamine is secreted by:

Enterochromaffin-like cell (ECL cell). ***Enterochromaffin-like cell (ECL cell)*** - **Enterochromaffin-like (ECL) cells** are located in the gastric mucosa and are the primary source of histamine in the stomach. - Histamine released by ECL cells stimulates **parietal cells** to secrete hydrochloric acid. - Note: ECL cells are distinct from enterochromaffin (EC) cells, which primarily secrete serotonin. *Chief cell* - **Chief cells** primarily secrete pepsinogen, the inactive precursor of the digestive enzyme pepsin. - They also produce gastric lipase, which aids in fat digestion. *Oxyntic cell* - The term **oxyntic (or parietal) cell** refers to the same cell type responsible for secreting hydrochloric acid and intrinsic factor. - They do not directly secrete histamine; instead, their acid secretion is stimulated by histamine. *Parietal cell* - **Parietal cells** are responsible for secreting hydrochloric acid and intrinsic factor, crucial for vitamin B12 absorption. - Their acid secretion is stimulated by acetylcholine, gastrin, and **histamine** (released from ECL cells).

Q: Delivery of stimulus above threshold intensity leads to a constant amplitude of AP and is known as:

All or none law. ***All or none law*** - The **all-or-none law** states that if a stimulus reaches or exceeds the **threshold intensity**, a neuron will fire an action potential of a constant, maximal amplitude. - If the stimulus is below the threshold, no action potential will fire, meaning there is no partial or submaximal action potential. *Electrotonic potential* - **Electrotonic potentials** are subthreshold, local changes in membrane potential that decay with distance and time. - They are **graded**, meaning their amplitude is proportional to the stimulus intensity, unlike the fixed amplitude of an action potential. *Absolute refractory period* - The **absolute refractory period** is the time during an action potential when the membrane is completely unresponsive to further stimulation, no matter how strong. - This period is due to the **inactivation of voltage-gated sodium channels**, preventing another action potential from being generated. *Relative refractory period* - The **relative refractory period** is the time following the absolute refractory period when a **larger-than-normal stimulus** is required to elicit another action potential. - This occurs because some potassium channels are still open, and the membrane is hyperpolarized, making it harder to reach the threshold.

Q: The primary dopaminergic reward center in the brain is?

Ventral tegmental area. ***Ventral tegmental area*** - The **ventral tegmental area (VTA)** is a key component of the mesolimbic dopamine system, often referred to as the **reward pathway** in the brain. - It projects dopamine neurons to various areas, including the **nucleus accumbens** and prefrontal cortex, mediating feelings of pleasure and reward. *Hippocampus* - The **hippocampus** is primarily involved in **memory formation** and spatial navigation. - While it interacts with reward pathways, it is not the primary dopaminergic reward center itself. *Amygdala* - The **amygdala** is critical for processing **emotions**, particularly fear and aggression, and plays a role in emotional memory. - It modulates reward responses but is not the primary source of dopaminergic reward signaling. *Thalamus* - The **thalamus** acts as a **relay station** for sensory information, directing it to appropriate cortical areas. - It has diverse functions but is not recognized as the central dopaminergic reward area.

Q: Ectopia lentis in a child is seen in which of the following diseases?

Homocystinuria. ***Homocystinuria*** - Ectopia lentis (lens dislocation) is a characteristic feature of **homocystinuria**, often presenting at a young age. - The dislocation in homocystinuria is typically **inferomedial (inferonasally)** due to weakened zonular fibers. - Homocystinuria is an **inborn error of methionine metabolism** with elevated homocysteine levels. *Marfan syndrome* - While **Marfan syndrome** is the most common cause of ectopia lentis, the lens typically dislocates **superiorly and temporally**. - Marfan syndrome is a connective tissue disorder but is not primarily a metabolic disorder like homocystinuria. - Both conditions can present with ectopia lentis, but the direction of dislocation and associated features differ. *Sarcoidosis* - Ocular manifestations of sarcoidosis usually include **uveitis**, **conjunctivitis**, and **retinal vasculitis**, but not typically ectopia lentis. - Sarcoidosis is a multisystem granulomatous disease and is rare in young children presenting with ectopia lentis. *Wilson disease* - **Kayser-Fleischer rings**, which are deposits of copper in the cornea, are pathognomonic for Wilson disease. - Ocular involvement in Wilson disease does not typically involve ectopia lentis. *Alkaptonuria* - This condition is characterized by the accumulation of **homogentisic acid**, leading to **ochronosis** (black pigmentation) in cartilaginous tissues and urine that turns black on standing. - Ocular manifestations can include scleral pigmentation, but ectopia lentis is not a feature of alkaptonuria.

Question 1

Which bone connects the sternum to the scapula?

Accepted Answer

Clavicle

Answer

First rib

Answer

Manubrium

Answer

Second rib

Question 2

Intellectual disability is seen in?

Accepted Answer

Phenylketonuria

Answer

Von Gierke disease

Answer

Alkaptonuria

Answer

Albinism

Question 3

A patient presented with 2 days history of fever. On examination there was a swelling in the neck and one side tonsil was pushed to midline. What is the most likely diagnosis:-

Accepted Answer

Quinsy

Answer

Retropharyngeal abscess

Answer

Parapharyngeal abscess

Answer

Tonsillitis

Question 4

Which one of the following is a major component in activation of the complement alternative pathway?

Accepted Answer

C3

Answer

C2

Answer

C4

Answer

C1

Question 5

Campimetry is used to measure:

Accepted Answer

Field of Vision

Answer

Squint

Answer

Pattern of retina

Answer

Malignant melanoma

Question 6

Which of the following drugs is a direct inhibitor of clotting factor Xa?

Accepted Answer

Apixaban

Answer

Argatroban

Answer

Fondaparinux

Answer

Aspirin

Question 7

Histamine is secreted by:

Accepted Answer

Enterochromaffin-like cell (ECL cell)

Answer

Chief cell

Answer

Oxyntic cell

Answer

Parietal cell

Question 8

Delivery of stimulus above threshold intensity leads to a constant amplitude of AP and is known as:

Accepted Answer

All or none law

Answer

Electrotonic potential

Answer

Absolute refractory period

Answer

Relative refractory period

Question 9

The primary dopaminergic reward center in the brain is?

Accepted Answer

Ventral tegmental area

Answer

Hippocampus

Answer

Amygdala

Answer

Thalamus

Question 10

Ectopia lentis in a child is seen in which of the following diseases?

Accepted Answer

Homocystinuria

Answer

Sarcoidosis

Answer

Wilson disease

Answer

Alkaptonuria

Answer

Marfan syndrome

FMGE 2018

Anatomy

Biochemistry

ENT

Microbiology

Ophthalmology

Pharmacology

Physiology

Psychiatry