Tubular Reabsorption and Secretion Practice Questions

Question 1

Mechanism of action of thiazides is by -

Accepted Answer

Inhibiting Na+/Cl- symporter in DCT

Answer

Inhibiting Na+K+2Cl- in ascending limb of loop of henle

Answer

Inhibiting Na+/Cl- symporter in PCT

Answer

Inhibiting Na+K+2Cl- in descending limb of loop of henle

Question 2

Which of the following statements is MOST true regarding water reabsorption in the nephron?

Accepted Answer

The bulk of water reabsorption occurs in the proximal tubule secondary to Na+ reabsorption.

Answer

Facultative reabsorption primarily occurs in the collecting ducts.

Answer

Obligatory reabsorption occurs regardless of hydration state.

Answer

Water reabsorption can vary significantly depending on the body's hydration needs.

Question 3

What happens to the concentration of inulin as fluid passes through the Proximal Convoluted Tubule (PCT)?

Accepted Answer

Concentration of inulin increases

Answer

Concentration of urea remains constant

Answer

Concentration of HCO3- increases

Answer

Concentration of Na+ decreases

Question 4

Increased aldosterone and ADH secretion following major trauma results in all the following except?

Accepted Answer

Increased water excretion

Answer

Increased osmolarity of urine

Answer

Increased K+ excretion in urine

Answer

Decreased Na+ excretion in urine

Question 5

Which of the following statements about the biodisposition of penicillins and cephalosporins is NOT accurate?

Accepted Answer

Renal tubular reabsorption of beta-lactams is inhibited by probenecid

Answer

Procaine penicillin G is used for intramuscular injection

Answer

Nafcillin and ceftriaxone are eliminated mainly by biliary secretion

Answer

Oral bioavailability is affected by lability to gastric acid

Question 6

Which substance has the least renal clearance?

Accepted Answer

Glucose

Answer

Inulin

Answer

Urea

Answer

Creatinine

Question 7

Mechanism of action of exenatide in diabetes mellitus is

Accepted Answer

It is analogue of GLP released from gut and increases glucose dependent insulin secretion

Answer

It is DPP-4 inhibitor and results in decreased breakdown of GLP

Answer

It is amylin analogue and decreases glucagon

Answer

It inhibits SGLT-2 and causes glucosuria

Question 8

Which of the following is a cause of hypokalemic metabolic alkalosis with hypertension?

Accepted Answer

Liddle syndrome

Answer

Bartter syndrome

Answer

Gitelman syndrome

Answer

Renal tubular acidosis

Question 9

The Renal function is best assessed by:

Accepted Answer

Tc 99m MAG3

Answer

Tc 99m DMSA

Answer

Tc 99m DTPA

Answer

Tc 99m pertechnetate

Question 10

Angiotensin II causes all of the following except:

Accepted Answer

Vasodilation

Answer

Stimulation of thirst

Answer

Increased ADH secretion

Answer

Aldosterone secretion

Tubular Reabsorption and Secretion — MCQs

Tubular Reabsorption and Secretion — MCQs

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