Hormone Receptors and Signaling Practice Questions

Question 1

Insulin acts by which pathway-

Accepted Answer

Tyrosine kinase

Answer

Intrinsic ion channel

Answer

JAK-STAT-Kinase

Answer

Transcription factor

Question 2

Which of the following hormones does not mediate its action through cAMP?

Accepted Answer

Estrogen

Answer

Glucagon

Answer

Follicle stimulating hormone

Answer

Luteinizing hormone

Question 3

Which of the following statements best describes the mechanism of action of insulin on target cells?

Accepted Answer

Insulin binds to a transmembrane receptor on the outer surface of the plasma membrane, activating the tyrosine kinase in the cytosolic domain of the receptor.

Answer

Insulin binds to a receptor on the outer surface of the plasma membrane, activating adenylate cyclase through the Gs protein.

Answer

Insulin binds to a cytoplasmic receptor and is transferred as a hormone receptor complex to the nucleus to modulate gene expression.

Answer

Insulin enters the cell and causes the release of calcium ions from intracellular stores.

Question 4

All these hormones primarily use cyclic adenosine monophosphate (cAMP) as their main second messenger pathway, except:

Accepted Answer

Dopamine

Answer

Glucagon

Answer

vasopressin

Answer

Corticotropin

Question 5

All the following mediate their action using cAMP as second messenger except:

Accepted Answer

Vasopressin

Answer

Glucagon

Answer

Dopamine

Answer

Corticotropin

Question 6

Which of the following binds to intracellular receptors?

Accepted Answer

Estrogen

Answer

Growth hormone

Answer

Vitamin E

Answer

Insulin

Question 7

Regarding thyroid hormone all are true except:

Accepted Answer

T4 has shorter half life than T3

Answer

T4 has the maximum plasma concentration

Answer

T3 is more avidly bound to nuclear receptors than T4

Answer

T3 is more active than T4

Question 8

What is the primary effect of GLP-1 on insulin secretion?

Accepted Answer

Increased insulin secretion from beta-cells of pancreas

Answer

Increased aldosterone secretion by adrenal

Answer

Increased PTH secretion

Answer

Increased testosterone secretion from Leydig cells

Question 9

Secretion of prolactin is inhibited by?

Accepted Answer

Dopamine

Answer

Serotonin

Answer

Noradrenaline

Answer

Adrenaline

Question 10

Which of the following statements about G protein-coupled receptors (GPCRs) is true?

Accepted Answer

G proteins can act as either inhibitory or excitatory based on the type of alpha subunit.

Answer

The three subunits alpha, beta, and gamma must remain together as a complex for G protein to function.

Answer

G proteins bind directly to hormones to become activated.

Answer

In the resting state, G proteins are bound to GTP.

Hormone Receptors and Signaling — MCQs

Hormone Receptors and Signaling — MCQs

Want unlimited practice?