Immunological Memory and Tolerance Practice Questions

Question 1

Which of the following statements about the secondary immune response is false?

Accepted Answer

Immune response against a subsequent antigenic challenge is absent.

Answer

The lag period is absent or significantly shorter.

Answer

There is a negative phase in the response.

Answer

Only T-dependent antigens are recognized.

Question 2

Which of the following is a specific feature of acquired immunity?

Accepted Answer

Immunological memory

Answer

Affected by genetic makeup

Answer

No antigen exposure

Answer

Immediate response

Question 3

Cell surface molecules involved in peripheral tolerance induction are

Accepted Answer

B7 and CD28

Answer

CD40 and CD40L

Answer

CD34 and CD51

Answer

B7 and CD3

Question 4

All are true regarding the development of T-cells, except?

Accepted Answer

T-cells are located in mantle layer of spleen

Answer

T-cells are formed in bone marrow

Answer

In lymph nodes, T-cells are found in paracortical area

Answer

Maturation of T-cells take place in thymus

Question 5

Which of the following statements regarding rejection of solid organ transplants is true?

Accepted Answer

Hyperacute rejection begins in the operating room with reperfusion of the transplanted organ

Answer

Most immunosuppressive medications are used to prevent chronic rejection

Answer

The major cause of graft failure is acute rejection

Answer

Liver transplants are especially susceptible to hyperacute rejection

Question 6

What is the inheritance pattern of the ABO blood group system and the HLA system?

Accepted Answer

Codominant

Answer

Pseudodominance

Answer

Autosomal dominant

Answer

Autosomal recessive

Question 7

All of the following are functions of the spleen EXCEPT?

Accepted Answer

Initiation of adaptive immune response from filtration of lymph.

Answer

Clearance of damaged or aged red blood cells (RBCs) from the blood.

Answer

Extramedullary site for hematopoiesis and recycling iron.

Answer

Clearance of encapsulated bacteria from the bloodstream.

Question 8

What is the first cell in the development of red blood cells?

Accepted Answer

Proerythroblast

Answer

Intermediate normoblast

Answer

Reticulocyte

Answer

Basophilic erythroblast

Question 9

The biconcave shape of RBC is useful for all the following functions EXCEPT:

Accepted Answer

Increasing surface area for diffusion

Answer

Allows considerable alteration in cell volume

Answer

Resisting hemolysis

Answer

Passing easily through smaller capillaries

Question 10

Which of the following is responsible for the adhesion of platelets to the vessel wall?

Accepted Answer

Von Willebrand factor

Answer

Factor IX

Answer

Fibrinogen

Answer

Fibronectin

Immunological Memory and Tolerance — MCQs

Immunological Memory and Tolerance — MCQs

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