Drug Efficacy and Potency Practice Questions

Question 1

The therapeutic index of a drug is defined as the ratio between the toxic dose and the effective dose.

Accepted Answer

Ratio of toxic dose to effective dose

Answer

Margin of safety

Answer

Efficacy of the drug

Answer

Drug potency

Question 2

Which of the following statements is correct regarding the given graph?

Accepted Answer

Drug 1 represents agonist and drug 4 represents inverse agonist

Answer

Drug 1 represents agonist and drug 2 represents inverse agonist

Answer

Drug 3 represents agonist and drug 4 represents inverse agonist

Answer

Drug 2 represents partial agonist and drug 3 represents inverse agonist

Question 3

Which of the following best demonstrates the variability in drug responsiveness among individuals?

Accepted Answer

Quantal Dose Response Curve

Answer

Potency

Answer

Efficacy

Answer

Graded Dose Response Curve

Question 4

Therapeutic index of a drug is an indicator of:-

Accepted Answer

Safety

Answer

All of these

Answer

Potency

Answer

Efficacy

Question 5

Which of the following statement is correct regarding the given DRC? (AllMS Nov 2016)

Accepted Answer

A and B are full agonists

Answer

C is non-competitive antagonist

Answer

B is more potent than A

Answer

A is more efficacious than B

Question 6

A 70 kg man was given a drug with a dose of 100 mg/kg body weight, twice daily. The half-life (t1/2) is 10 hours, the plasma concentration is 1.9 mg/mL, and the clearance is unknown. What is the clearance of this drug?

Accepted Answer

0.22 L/hr

Answer

20 liter/hr

Answer

K is 0.0693

Answer

0.02 L/hr

Question 7

The graph below shows dose-response curves for three drugs A, B, and C. Which of the following drugs has the highest potency?

Accepted Answer

Drug A

Answer

Drug B

Answer

Drug C

Answer

Both Drug A & B

Question 8

What is the shelf life of Dukoral (wc-rBS) oral vaccine used for cholera prevention, when stored at a temperature of 2 °C to 8 °C?

Accepted Answer

2 years

Answer

3 years

Answer

6 months

Answer

5 years

Question 9

Which drug is metabolized by glutathionation?

Accepted Answer

Dapsone

Answer

Nicotinic acid

Answer

Fosfomycin

Answer

Benzodiazepines

Question 10

What do A and B represent in the curve shown below?

Accepted Answer

A= Median effective dose, B= Median lethal dose

Answer

A= Therapeutic index, B= Median efficacy

Answer

A= Median lethal dose, B= Median effective dose

Answer

A= Median efficacy, B= Therapeutic index

Drug Efficacy and Potency — MCQs

Drug Efficacy and Potency — MCQs

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