Cytochrome P450 Polymorphisms — MCQs

The cytochrome involved in monooxygenase-mediated detoxification of drugs is:

Which of the following is the platinum-based chemotherapeutic agent used as first-line treatment for ovarian carcinoma?

Match the following drugs in Column A with their contraindications in Column B. | Column A | Column B | | :-- | :-- | | 1. Morphine | 1. QT prolongation | | 2. Amiodarone | 2. Thromboembolism | | 3. Vigabatrin | 3. Pregnancy | | 4. Estrogen preparations | 4. Head injury |

Which of the following cytochromes is involved in monooxygenase mediated detoxification of drugs?

A lady gets pregnant even though she was on contraceptive pills. She is suspected to have consumed

Which of the following combinations can result in severe toxicity due to inhibition of cytochrome P450 enzymes?

Centrilobular necrosis of the liver may be seen with?

Chemical process involved in conversion of progesterone to glucocorticoids is

Drugs used for Prophylaxis of migraine include the following except?

Testing of HLA-B' 5701 is recommended prior to initiation of which antiretroviral agent?