Age-Related Changes in Pharmacodynamics Practice Questions

Question 1

What is the most consistent cardiovascular effect of hypothermia in elderly patients?

Accepted Answer

Decreased heart rate

Answer

May cause myocardial infarction

Answer

Decreased cardiac output

Answer

All of the options

Question 2

Newborns as compared to adults eliminate lidocaine:

Accepted Answer

More slowly

Answer

Variable

Answer

More rapidly

Answer

Equally fast

Question 3

Which of the following drug causes postural hypotension commonly?

Accepted Answer

Alpha blocker

Answer

Angiotensin receptor blockers

Answer

Beta blocker

Answer

ACE inhibitor

Question 4

Which of the following statements about the differences between neonates and adults is true?

Accepted Answer

Their excretory ability of the kidney is less well developed.

Answer

They can tolerate large doses of certain drugs on body weight basis.

Answer

Their gastric emptying is prolonged.

Answer

Their hepatic metabolizing enzyme activity is slower.

Question 5

All of the following drugs cross the blood-brain barrier, EXCEPT:

Accepted Answer

Neostigmine

Answer

Physostigmine

Answer

Atropine

Answer

Lignocaine

Question 6

Which of the following is not a component of the Goldman Revised Cardiac Risk Index?

Accepted Answer

Age > 80 yrs

Answer

History of preoperative treatment with insulin

Answer

History of preoperative serum creatinine >2.0 mg/dL

Answer

History of ischemic heart disease

Question 7

A mother reports that her daughter ingested a substance in an unknown dose. The girl presents with hypertension, tachycardia, mydriasis, and hyperthermia. What is the most likely substance?

Accepted Answer

Cocaine

Answer

Heroin

Answer

Morphine

Answer

Chlorpheniramine

Answer

Organophosphate

Question 8

What do A and B represent in the curve shown below?

Accepted Answer

A= Median effective dose, B= Median lethal dose

Answer

A= Therapeutic index, B= Median efficacy

Answer

A= Median lethal dose, B= Median effective dose

Answer

A= Median efficacy, B= Therapeutic index

Question 9

For the treatment of kala-azar, the daily dose of miltefosine in a 3-year-old child who weighs 15 kg is

Accepted Answer

40 mg

Answer

20 mg

Answer

10 mg

Answer

30 mg

Question 10

Which of the following is a characteristic feature of Werner's syndrome?

Accepted Answer

Accelerated aging

Answer

Joint laxity

Answer

Multiple cancers

Answer

Intestinal polyps

Age-Related Changes in Pharmacodynamics — MCQs

Age-Related Changes in Pharmacodynamics — MCQs

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