Pharmacogenetics and Personalized Medicine — MCQs
HLA-B*5701 is an allele associated with hypersensitivity to abacavir. Which of the following is the parent allele of HLA-B*5701?
Mutation in GLUT-2 causes which syndrome?
Variation in sensitivity of response to different doses of a drug in different individuals is obtained from?
Mutations are due to changes in:
What is the primary purpose of xenobiotic metabolism?
Which of the following statements about phase IV clinical trials is correct?
Match the following drugs in Column A with their contraindications in Column B. | Column A | Column B | | :-- | :-- | | 1. Morphine | 1. QT prolongation | | 2. Amiodarone | 2. Thromboembolism | | 3. Vigabatrin | 3. Pregnancy | | 4. Estrogen preparations | 4. Head injury |
Which of the following cytochromes is involved in monooxygenase mediated detoxification of drugs?
A patient is on warfarin therapy. All of the following drugs increase the risk of bleeding with warfarin except?
Morphine should not be used in the treatment of:
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