Pharmacokinetic Interactions Practice Questions

Question 1

Pharmacodynamics deals with:-

Accepted Answer

Mechanism of action of a drug

Answer

Latency of onset

Answer

Transport of drug across the biological membranes

Answer

Mode of excretion of a drug

Question 2

Which of the following is NOT a mechanism of antibiotic resistance?

Accepted Answer

Increased drug absorption

Answer

Efflux pump activity

Answer

Inactivation by enzymes such as beta-lactamase

Answer

Modification of drug target sites

Question 3

What is the primary role of Cytochrome P450 enzymes in the liver?

Accepted Answer

Oxidation of drugs

Answer

Lipid transport

Answer

Carbohydrate synthesis

Answer

Protein degradation

Question 4

What is the mechanism of metabolism for alcohol, aspirin, and phenytoin at high doses?

Accepted Answer

Zero order kinetics

Answer

First pass kinetics

Answer

First order kinetics

Answer

Second order kinetics

Question 5

Which of the following medications does not interact with warfarin?

Accepted Answer

Benzodiazepines

Answer

Barbiturate

Answer

Oral contraceptive

Answer

Cephalosporins

Question 6

Drug X has an affinity for albumin, while drug Y has 150 times greater affinity. Which of the following statements is MOST accurate?

Accepted Answer

The free concentration of drug X in blood is higher, facilitating tissue distribution.

Answer

Drug X will be more available in tissues

Answer

Drug Y will be less available in tissues

Answer

Toxicity of drug Y may be influenced by multiple factors, not just its binding.

Question 7

Which drug has the highest plasma protein binding?

Accepted Answer

Warfarin

Answer

Verapamil

Answer

Aspirin

Answer

GTN

Question 8

At toxic doses, zero-order kinetics is seen in which of the following substances?

Accepted Answer

Phenytoin

Answer

Valproate

Answer

Carbamazepine

Answer

Penicillin

Question 9

Identify the false statement regarding suicide inhibition

Accepted Answer

The inhibitor can bind with any site resulting in suicidal inhibition

Answer

The binding of the enzyme to the substrate analogue is irreversible

Answer

The inhibitor forms a product with the enzyme and the product inhibits it

Answer

They are enzyme specific and used in rational drug design

Question 10

What is the mechanism of action of thiazides?

Accepted Answer

Na+Cl- co-transporter inhibitor

Answer

Carbonic anhydrase inhibitor

Answer

Osmotic diuresis

Answer

Na+K+ co-transporter inhibitor

Pharmacokinetic Interactions — MCQs

Pharmacokinetic Interactions — MCQs

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