Principles of Clinical Pharmacology — MCQs

Which of the following best demonstrates the variability in drug responsiveness among individuals?

A 70 kg man was given a drug with a dose of 100 mg/kg body weight, twice daily. The half-life (t1/2) is 10 hours, the plasma concentration is 1.9 mg/mL, and the clearance is unknown. What is the clearance of this drug?

Identify the correct match, regarding the drug and its adverse effect.

What is the mechanism of action of ticagrelor?

In which phase of clinical trials is drug dosing typically determined?

A drug is more likely to cause toxicity in elderly patients due to all of the following reasons except which of the following?

Which statement best describes first-order kinetics in pharmacokinetics?

Match the following drugs in Column A with their contraindications in Column B. | Column A | Column B | | :-- | :-- | | 1. Morphine | 1. QT prolongation | | 2. Amiodarone | 2. Thromboembolism | | 3. Vigabatrin | 3. Pregnancy | | 4. Estrogen preparations | 4. Head injury |

Which of the following best describes a Type B adverse drug reaction?

What is the treatment of choice for a 5-year-old child with bedwetting?