Neoplasia Practice Questions

Q: Choristoma is defined as:

Normal tissue in an abnormal site. **Explanation:** **Choristoma** is a developmental anomaly characterized by the presence of **microscopically normal cells or tissues in an abnormal anatomical location** [1]. It is a form of heterotopia or ectopia [1]. Although it presents as a mass and can mimic a neoplasm, it is not a true tumor but rather a congenital malformation. **Analysis of Options:** * **Option A (Correct):** This is the definition of Choristoma. A classic example is a nodule of well-organized pancreatic tissue found in the submucosa of the stomach or small intestine [1]. * **Option B (Incorrect):** This describes a **Hamartoma**. A hamartoma consists of an excessive, disorganized growth of mature cells and tissues indigenous to that particular site (e.g., a pulmonary hamartoma containing cartilage, bronchial epithelium, and connective tissue in the lung). * **Option C (Incorrect):** This is a vague description that could apply to various conditions, including dysplasia or neoplasia, but it does not define the specific developmental entity of choristoma. **High-Yield Clinical Pearls for NEET-PG:** * **Choristoma vs. Hamartoma:** Remember the mnemonic: **C**horistoma is **C**onfused (wrong place), **H**amartoma is **H**ome (right place, wrong organization). * **Common Examples of Choristoma:** 1. Pancreatic tissue in the stomach or Meckel’s diverticulum [1]. 2. Adrenal rest tissue in the kidney, ovary, or testis. 3. Gastric mucosa in the distal esophagus (Inlet patch) [1]. * **Key Feature:** Both choristomas and hamartomas are **benign** and grow at a rate similar to the surrounding tissues, unlike true neoplasms which exhibit autonomous growth. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Gastrointestinal Tract, pp. 757-759.

Question 1

Teratoma arises from which type of cells?

Accepted Answer

Totipotent cells

Answer

Mesodermal cells

Answer

Ectodermal cells

Answer

Endodermal cells

Question 2

Which of the following conditions has an increased risk of malignancy?

Accepted Answer

All of the above

Answer

Metaplasia

Answer

Dysplasia

Answer

Hyperplasia

Question 3

The Epstein Barr virus is implicated in all of the following conditions, EXCEPT?

Accepted Answer

Leukemia

Answer

Nasopharyngeal carcinoma

Answer

Burkitt's lymphoma

Answer

Infectious mononucleosis

Question 4

Which of the following is involved in the tumor metastasis cascade?

Accepted Answer

E-Cadherin

Answer

Fibronectin

Answer

Type IV collagenase

Answer

Tyrosine kinase

Question 5

Choristoma is defined as:

Accepted Answer

Normal tissue in an abnormal site

Answer

Normal tissue in excess at a normal site

Answer

Abnormal tissue at any site

Answer

None of the above

Question 6

What is the diagnostic electron microscopy feature of Paragangliomas?

Accepted Answer

Dense neurosecretory granules

Answer

Small nests of round to ovoid cells with scarce cytoplasm

Answer

Mononuclear infiltrate with bizarre nuclei in perineural tissue

Answer

Lipofuscin deposits in perinuclear, intra-lysosomal location

Question 7

Which of the following terms best describes a round cell malignancy?

Accepted Answer

Poorly differentiated

Answer

Well differentiated

Answer

Moderately differentiated

Answer

None of the above

Question 8

In retinoblastoma, after enucleation, which tissue is sectioned to find out systemic metastasis?

Accepted Answer

Optic nerve

Answer

Central retinal artery

Answer

Sclera and episclera

Answer

Vortex vein

Question 9

All of the following tumours are associated with organisms except?

Accepted Answer

Non-small cell lung carcinoma

Answer

Gastric carcinoma

Answer

Hepatocellular carcinoma

Answer

Nasopharyngeal carcinoma

Question 10

Which of the following is associated with von Hippel-Lindau disease?

Accepted Answer

Cavernous hemangioma

Answer

Pyogenic granuloma

Answer

Juvenile hemangioma

Answer

Capillary hemangioma

Neoplasia — MCQs

Neoplasia — MCQs

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