Neoplasia — MCQs

A clinical study involves patients diagnosed with carcinoma whose tumor stage is T4N1M1. The patients' survival rate 5 years from the time of diagnosis is less than 50%, regardless of therapy. Which of the following clinical findings is most likely to be characteristic of this group of patients?

Which of the following changes in the C-MYC oncogene may be associated with colonic malignancy?

Which of the following statements is TRUE about Tumor suppressor gene p53?

Anaplasia is a hallmark feature of which of the following?

Hypercalcemia is most commonly associated with which of the following cancers?

What is the mechanism by which the tumor suppressor gene p53 prevents carcinoma?

Which of the following is assessed by the Bloom-Richardson grading system?

A 59-year-old male is found to have a 3.5-cm mass in the right upper lobe of his lung. A biopsy of this mass is diagnosed as a moderately differentiated squamous cell carcinoma. Workup reveals that no bone metastases are present, but laboratory examination reveals that the man's serum calcium levels are 11.5 mg/dL. This patient's paraneoplastic syndrome is most likely the result of ectopic production of which of the following?

Which gene is involved in Cowden syndrome?

A 5-year-old child presents with a lesion in the right eye. Histopathology reveals the presence of Flexner-Wintersteiner rosettes. What is the likely diagnosis?