Neoplasia Practice Questions

Q: Which of the following is an odontogenic tumor?

Ameloblastoma. **Explanation:** **Ameloblastoma (Option C)** is the correct answer. It is a slow-growing, locally invasive, but usually benign epithelial tumor arising from **odontogenic epithelium** (remnants of the dental lamina or enamel organ) [1]. It is the most common clinically significant odontogenic tumor [1]. **Analysis of Options:** * **Arrhenoblastoma (Option A):** Also known as a Sertoli-Leydig cell tumor, this is a rare **ovarian tumor** that secretes androgens, leading to virilization in females. * **Astrocytoma (Option B):** This is a primary **Central Nervous System (CNS) tumor** arising from astrocytes (glial cells). It is the most common glioma. * **Granular Cell Tumor (Option D):** Historically thought to be myogenic, it is now known to be a benign neuroectodermal tumor of **Schwann cell origin**. While it frequently occurs on the tongue, it is not odontogenic. **High-Yield Clinical Pearls for NEET-PG:** * **Radiology:** Ameloblastoma characteristically presents as a **"soap-bubble"** or "honeycomb" multilocular radiolucency, most commonly in the molar-ramus region of the mandible. * **Histopathology:** The classic "Follicular type" shows islands of epithelium with **peripheral palisading** of columnar cells (resembling ameloblasts) and central **stellate reticulum-like** cells. * **Vickers-Gorlin Criteria:** Used for histopathological diagnosis, focusing on reverse polarity of nuclei and subnuclear vacuolization. * **Treatment:** It requires wide surgical excision because it is locally aggressive with a high recurrence rate if merely curetted [1]. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Head and Neck, pp. 741-742.

Question 1

Alpha-fetoprotein (AFP) levels are increased in all of the following conditions except?

Accepted Answer

Seminoma

Answer

Pregnancy

Answer

Hepatocellular carcinoma (HCC)

Answer

Lung carcinoma

Question 2

What is the most common cause of death in patients with carcinoma?

Accepted Answer

Uremia

Answer

Hemorrhage

Answer

Infection

Answer

Metastasis

Question 3

Which of the following is a marker of carcinoma?

Accepted Answer

Cytokeratin

Answer

Vimentin

Answer

Calretinin

Answer

CD45

Question 4

Smoking causes all of the following cancers except:

Accepted Answer

Endometrial carcinoma

Answer

Oral cancer

Answer

Kidney cancer

Answer

Bladder cancer

Question 5

What is the most common tumor of infancy?

Accepted Answer

Rhabdomyoma

Answer

Lymphangioma

Answer

Hemangioma

Answer

Lipoma

Question 6

Alpha-fetoprotein levels are increased in which of the following conditions?

Accepted Answer

Hepatoblastoma

Answer

Neuroblastoma

Answer

Seminoma

Answer

Renal cell carcinoma

Question 7

Which of the following are included in the Modified Bloom Richardson criteria for Carcinoma Breast?

Accepted Answer

All of the above

Answer

Nuclear polymorphism

Answer

Tubule formation

Answer

Mitotic rate

Question 8

Which of the following is an odontogenic tumor?

Accepted Answer

Ameloblastoma

Answer

Arrhenoblastoma

Answer

Astrocytoma

Answer

Granular cell tumor

Question 9

Which of the following types of cancers is Human Papilloma Virus (HPV) most commonly associated with?

Accepted Answer

Anogenital

Answer

Prostate

Answer

Oral

Answer

Lung

Question 10

Psammoma bodies are seen in all of the following conditions except?

Accepted Answer

Follicular carcinoma of thyroid

Answer

Papillary carcinoma of thyroid

Answer

Serous cystadenocarcinoma of ovary

Answer

Meningioma

Neoplasia — MCQs

Neoplasia — MCQs

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